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Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
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通过PPARalpha进行对抗剂介导的核共抑制剂的招募的结构基础

H Eric Xu1, Thomas B Stanley, Valerie G Montana

  • 1Nuclear Receptor Discovery Research, GlaxoSmithKline, Research Triangle Park, NC 27709, USA. ex11957@gsk.com

Nature
|February 15, 2002
PubMed
概括

核受体通过共抑制剂抑制基因转录. 这项研究揭示了核受体-共抑制体综合体的晶体结构,阐明了基因抑制的保存机制.

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