参与认知刺激活动和发生阿尔茨海默病的风险
Robert S Wilson1, Carlos F Mendes De Leon, Lisa L Barnes
1Rush Alzheimer's Disease Center, 1645 W Jackson Blvd, Suite 675, Chicago, IL 60612, USA. rwilson@rush.edu
JAMA
|February 20, 2002
概括
参与精神刺激活动可能会降低阿尔茨海默病 (AD) 风险. 这项研究发现,频繁的认知活动与33%降低患AD的风险有关.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 公共卫生 公共卫生
背景情况:
- 认知刺激活动被假定可以降低阿尔茨海默病 (AD) 风险.
- 关于这个协会的前性数据是有限的.
研究的目的:
- 调查频繁参与认知活动与发展AD的风险之间的关联.
- 测试一个假设,即更高的认知活动是对AD的保护.
主要方法:
- 在801名没有痴呆症的老年天主教修女,神父和兄弟的纵向队列研究中.
- 基线认知活动频率使用经过验证的复合得分进行测量.
- 参与者被跟踪平均4.5年,以诊断AD和认知功能变化.
主要成果:
- 认知活动得分增加1点与AD风险降低33%有关 (HR,0.67).
- 在调整了年龄,性别,教育和其他因素后,这种关联仍然显著.
- 增加的认知活动也与全球认知,工作记忆和感知速度的下降相关.
结论:
- 经常参与认知刺激活动与阿尔茨海默病风险降低有关.
- 促进认知参与可能是预防AD的可行策略.
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