p53状态对瘤对抗血管生成疗法的反应的影响
Joanne L Yu1, Janusz W Rak, Brenda L Coomber
1Sunnybrook and Women's College Health Sciences Centre, Molecular and Cellular Biology Research, Room S-218, 2075 Bayview Avenue, Toronto, Ontario, Canada M4N 3M5.
Science (New York, N.Y.)
|February 23, 2002
概括
缺乏p53基因的瘤细胞显示减少了亡,对抗血管生成疗法反应不佳. 这突显了瘤细胞遗传学如何影响治疗的有效性,即使向瘤血管系统.
科学领域:
- 在瘤学瘤学.
- 癌症生物学 癌症生物学
- 分子医学是分子医学.
背景情况:
- 在人类癌症中,p53瘤抑制基因经常被禁用.
- 缺乏p53的瘤在缺氧下表现出减少的亡,可能降低血管依赖性.
- 这种减少的血管依赖性可能会对抗血管生成疗法产生耐药性.
研究的目的:
- 为了研究p53缺乏对瘤对抗血管原体组合疗法的反应的影响.
- 确定p53缺乏瘤的血管依赖性减少是否会影响治疗结果.
主要方法:
- 使用的同位素HCT116人类结直肠癌细胞系,有或没有p53 (p53 ((-/-) 与p53 ((+/+)).
- 对携带这些瘤的小鼠进行了抗血管原体组合疗法.
- 评估和比较两个组之间的瘤对治疗的反应.
主要成果:
- 与p53(-/-) HCT116瘤的小鼠相比,与p53(+/+) 瘤的小鼠相比,对抗血管原组合疗法的反应明显较小.
- 这表明p53缺乏影响瘤对瘤血管向治疗的敏感性.
结论:
- 降低瘤细胞血管依赖性的p53无活化等遗传变化可以调节治疗反应.
- 虽然抗血管生成疗法向内皮细胞,但瘤细胞的内在基因构成在治疗疗效方面起着至关重要的作用.
- 了解p53状态对于预测对抗血管生成策略的反应可能很重要.
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