Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Inflammation01:38

Inflammation

46.8K
Overview
46.8K
Attenuated Total Reflectance (ATR) Infrared Spectroscopy: Overview01:13

Attenuated Total Reflectance (ATR) Infrared Spectroscopy: Overview

1.5K
Attenuated total reflectance (ATR) infrared spectroscopy is a powerful analytical technique used to study the composition of materials. It is widely employed in chemistry, materials science, forensic science, and other fields where sample characterization is required. ATR has several advantages over traditional transmission IR spectroscopy, including the requirement of little to no sample preparation and the ability to analyze a wide range of samples.
The ATR process begins by directing a beam...
1.5K
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

2.5K
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
2.5K
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

961
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
961

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Measuring Aztreonam Variations by Process Analytical Technology.

Contact in context·2026
Same author

Serial OCT-based coronary physiology and plaque composition in vessels with nonobstructive coronary lesions following intensive lipid-lowering therapy: YELLOW III sub-study.

Atherosclerosis·2026
Same author

Intra-coronary imaging and transcriptomics of calcified nodules before and after intensive lipid-lowering therapy: a YELLOW III substudy.

European heart journal. Imaging methods and practice·2026
Same author

Rapid Quality Screening of Intra-lot Variability of Acetazolamide Using Near-Infrared Spectrometry.

Contact in context·2026
Same author

Spectral Intra-Lot and Inter-Lot Variability in Methacholine.

Contact in context·2026
Same author

Intracoronary Imaging and Transcriptomic Characteristics Before and After Maximum Lipid-Lowering Therapy: YELLOW-III Study of Evolocumab and Maximum Statin Therapy in Chronic Coronary Disease.

JACC. Cardiovascular imaging·2026

相关实验视频

Updated: May 5, 2026

In vivo Near Infrared Fluorescence NIRF Intravascular Molecular Imaging of Inflammatory Plaque, a Multimodal Approach to Imaging of Atherosclerosis
09:43

In vivo Near Infrared Fluorescence NIRF Intravascular Molecular Imaging of Inflammatory Plaque, a Multimodal Approach to Imaging of Atherosclerosis

Published on: August 4, 2011

17.5K

通过近红外光谱学检测人类大动脉动脉样硬化斑块中的脂质池,细纤维盖和炎症细胞.

Pedro R Moreno1, Robert A Lodder, K Raman Purushothaman

  • 1Linda and Jack Gill Heart Institute, University of Kentucky, Lexington, USA. pmoreno@uky.edu

Circulation
|February 28, 2002
PubMed
概括

近红外 (NIR) 光谱学准确地识别了脆弱的动脉样硬化斑块特征,包括脂质池和细纤维状盖. 这种方法对检测患者高风险冠状动脉斑块具有前途.

更多相关视频

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
08:43

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

19.7K
Author Spotlight: Enhancing Vascular Function and Physical Capacity in Cardiovascular Disease Through Novel Interventions and NIRS Technology
04:44

Author Spotlight: Enhancing Vascular Function and Physical Capacity in Cardiovascular Disease Through Novel Interventions and NIRS Technology

Published on: March 22, 2024

1.7K

相关实验视频

Last Updated: May 5, 2026

In vivo Near Infrared Fluorescence NIRF Intravascular Molecular Imaging of Inflammatory Plaque, a Multimodal Approach to Imaging of Atherosclerosis
09:43

In vivo Near Infrared Fluorescence NIRF Intravascular Molecular Imaging of Inflammatory Plaque, a Multimodal Approach to Imaging of Atherosclerosis

Published on: August 4, 2011

17.5K
Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
08:43

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

19.7K
Author Spotlight: Enhancing Vascular Function and Physical Capacity in Cardiovascular Disease Through Novel Interventions and NIRS Technology
04:44

Author Spotlight: Enhancing Vascular Function and Physical Capacity in Cardiovascular Disease Through Novel Interventions and NIRS Technology

Published on: March 22, 2024

1.7K

科学领域:

  • 生物医学工程 生物医学工程
  • 频谱学是一种光谱学.
  • 心血管病理学心血管病理学

背景情况:

  • 动脉样硬化斑块可能导致急性冠状动脉事件,需要方法来识别易受伤害的,非静脉样性,富含脂质的类型.
  • 近红外 (NIR) 光谱学提供了对组织化学成分的洞察力.

研究的目的:

  • 评估NIR光谱在识别斑块组成和脆弱性特征方面的有效性.
  • 测试NIR光谱能够检测脆弱的人类大动脉动脉样硬化斑块的假设.

主要方法:

  • 使用NIR光谱 (1100-2200nm) 分析了199个人类大动脉斑样本.
  • 组织学评估确定了斑块的脆弱性 (脂质池,薄盖,炎症).
  • 使用了主要组件回归和预测算法.

主要成果:

  • 尼尔射线光谱检测显示高灵敏度和特异性检测脂质池 (90%,93%),薄盖 (77%,93%) 和炎症细胞 (84%,89%).
  • 一个预测算法被开发和验证在一个单独的样本集.

结论:

  • 尼尔光谱学有效地识别了死后人类大动脉样本中的斑块组成和脆弱性特征.
  • 这些发现支持开发基于NIR光谱的导管系统,用于体内检测脆弱的冠状动脉斑块.