过氧体增殖器激活受体α基因调节左心室生长,以应对运动和高血压
Yalda Jamshidi1, Hugh E Montgomery, Hans-Werner Hense
1Centre for Cardiovascular Genetics, Department of Medicine, University College London Medical School, London, UK.
Circulation
|February 28, 2002
概括
过氧体增殖器激活受体α (PPARalpha) 基因的遗传变异会影响左心室生长以应对运动和高血压,影响左心室缩 (LVH) 的发展.
科学领域:
- 心血管生理学心血管生理学
- 分子遗传学 分子遗传学
- 人体生理学 人体生理学
背景情况:
- 左心室缩 (LVH) 是对心脏工作量增加的适应性反应,但其分子机制尚不清楚.
- 脂肪酸氧化的遗传缺陷与早期发作的心脏缩有关.
- 过氧体增殖器激活受体α (PPARalpha) 调节心肌脂肪酸氧化,并在心脏缩期间下调.
研究的目的:
- 研究PPARalpha基因变异在人类左心室生长中的作用.
- 为了确定PPARalpha是否影响LVH对运动和高血压的反应.
主要方法:
- 检查了144名英国陆军的男性新兵,他们正在接受体育训练.
- 分析了MONICA奥格斯堡研究中的1148名参与者的心声回声数据.
- 评估了PPARalpha基因在PPARalpha基因第7个内突中的G/C多态性对左心室 (LV) 质量的影响.
主要成果:
- 在PPARalpha基因中的G/C多态性显著影响了对运动反应的LV增长 (P=0.009).
- 具有C等位基因的个体与G等位基因同胞相比,LV质量增加更大.
- 具有C等位基的同位基体表现出更高的LV质量和更高的LVH患病率,特别是在高血压患者中.
结论:
- PPARalpha基因的变异会影响人类由于运动和高血压导致的左心室生长.
- 受到PPARalpha影响的不适应性心脏基质利用可能有助于LVH的发病.
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