生物催化路径到周围糖核构建的定义良好的巨体
Rajesh Kumar1, Richard A Gross
1NSF Center for Biocatalysis and Bioprocessing of Macromolecules, Department of Chemistry and Chemical Engineering, Polytechnic University, Six Metrotech Center, Brooklyn, New York 11201, USA.
Journal of the American Chemical Society
|February 28, 2002
概括
研究人员开发了一种新的方法,使用脂酶催化转换来精确地构建基于碳水化合物的宏体. 这种生物催化方法提供了对替代剂放置的特殊控制,使复杂的宏和星聚合物的合成成为可能.
科学领域:
- 碳水化合物化学 碳水化合物化学
- 聚合物科学 聚合物科学
- 生物催化剂是一种生物催化剂.
背景情况:
- 使用传统合成方法,精确控制宏结构是具有挑战性的.
- 碳水化合物核心为先进材料提供独特的结构可能性.
研究的目的:
- 开发一种灵活的方法来合成基于碳水化合物的宏体,并控制替代剂的放置.
- 探索使用脂酶催化转换来创建复杂的聚合物架构.
主要方法:
- 选择性脂酶催化合一种带有高二聚体过剩的多原衍生物.
- 从糖核开始的epsilon-caprolactone的环开放聚合.
- 酶性化和水解步骤来修改宏体结构.
- 合成的烯酸糖封顶巨合物的同聚合.
主要成果:
- 在碳水化合物核心周围成功合成了一种具有精确替代物放置的宏.
- 在化步骤中实现了高体过剩 (高达93%).
- 制造出明确的多分子链,具有受控的分子量和低的多分散性.
- 证明了产生各种宏和恒星聚合物的方法的灵活性.
结论:
- 脂酶催化转换在宏合成中提供了特殊的控制.
- 开发的方法可以创建基于碳水化合物的复杂聚合物,否则很难获得.
- 这种方法有可能产生广泛的新型宏和异构臂恒星聚合物.
相关概念视频
What is Metabolism?
Overview
What is Glycolysis?
Overview
Cells make energy by breaking down macromolecules. Cellular respiration is the biochemical process that converts "food energy" (from the chemical bonds of macromolecules) into chemical energy in the form of adenosine triphosphate (ATP). The first step of this tightly regulated and intricate process is glycolysis. The word glycolysis originates from the Latin glyco (sugar) and lysis (breakdown). Glycolysis serves two main intracellular functions: generating ATP and generating...
Cells make energy by breaking down macromolecules. Cellular respiration is the biochemical process that converts "food energy" (from the chemical bonds of macromolecules) into chemical energy in the form of adenosine triphosphate (ATP). The first step of this tightly regulated and intricate process is glycolysis. The word glycolysis originates from the Latin glyco (sugar) and lysis (breakdown). Glycolysis serves two main intracellular functions: generating ATP and generating...
Oligosaccharide Assembly
Protein glycosylation starts in the ER lumen and continues in the Golgi apparatus. Glycosyltransferases catalyze the addition of sugar molecules or glycosylation of proteins. Usually, these enzymes add sugars to the hydroxyl groups of selected serine or threonine residues to form O-linked glycans or the amino groups of asparagine residues to form N-linked glycans. Different positions on the same polypeptide chain can contain differently linked glycans.
Multiple sugar molecules that may or may...
Multiple sugar molecules that may or may...
Sugars as Energy Storage Molecules
Sugar (a simple carbohydrate) metabolism (chemical reactions) is a classic example of the many cellular processes that use and produce energy. Living things consume sugar as a major energy source because sugar molecules have considerable energy stored within their bonds. Consumed carbohydrates have their origins in photosynthesizing organisms like plants. During photosynthesis, plants use the energy of sunlight to convert carbon dioxide gas into sugar molecules, like glucose. Because this...
Sugars as Energy Storage Molecules
Sugar (a simple carbohydrate) metabolism (chemical reactions) is a classic example of the many cellular processes that use and produce energy. Living things consume sugar as a major energy source because sugar molecules have considerable energy stored within their bonds. Consumed carbohydrates have their origins in photosynthesizing organisms like plants. During photosynthesis, plants use the energy of sunlight to convert carbon dioxide gas into sugar molecules, like glucose. Because this...
Biosynthesis of Polysaccharides
Polysaccharides such as glycogen and starch are synthesized from nucleoside diphosphate sugars, primarily uridine diphosphate glucose (UDPG) and adenosine diphosphate glucose (ADPG). These activated glucose donors act as key intermediates in carbohydrate metabolism and biosynthesis. UDPG primarily involves glycogen synthesis in animals and many bacteria, while ADPG plays a fundamental role in starch synthesis in plants and certain bacteria.UDPG is formed when glucose-1-phosphate reacts with...


