Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Biological Clocks and Seasonal Responses02:45

Biological Clocks and Seasonal Responses

The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Feedback Regulation of Calcium Concentration01:27

Feedback Regulation of Calcium Concentration

Calcium is an essential signaling molecule required for various cellular functions. Calcium pumps and ion channels on cell and organellar membranes, such as those on the endoplasmic reticulum (ER), regulate calcium concentrations inside the cell. They remain closed, keeping the cytosolic calcium levels low at a resting state.
Various transmembrane receptors, such as G protein-coupled receptors (GPCRs), elicit a response to extracellular signals by increasing cytosolic calcium. Activated GPCRs...
Setting Time of Cement01:12

Setting Time of Cement

The setting time of cement refers to the process of cement paste transitioning from a plastic state to a solid state. This process is crucial in construction as it dictates the timeframe for concrete placement, compaction, and finishing. The onset of this solidification is termed the initial set, indicating when the paste becomes unworkable. The final set is when the paste has solidified completely, and further handling or manipulation can no longer affect its shape. The cement strength is...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Continuous flash suppression responses in mouse visual cortex: Stimulus laterality and anesthesia effects.

iScience·2026
Same author

Could we perceive the world differently than we do? Neuroscience-based emergentism and the biological function of consciousness.

Consciousness and cognition·2026
Same author

Integrated information and predictive processing theories of consciousness: An adversarial collaborative review.

Neuroscience and biobehavioral reviews·2026
Same author

The Impact of a Gamified Engagement Toolkit on Heart Failure Registry Participation: Results of the Engage-HF Study.

European journal of cardiovascular nursing·2026
Same author

Heart failure patients with reduced or mildly reduced ejection fraction: baseline characteristics of the low-dose digoxin outcome DECISION trial.

European journal of heart failure·2026
Same author

How can we validate theory-derived indicators of consciousness in Artificial Intelligence?

Trends in cognitive sciences·2026

相关实验视频

Updated: May 10, 2026

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
06:53

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

哺乳动物昼夜时钟中节制起器潜力和电流的日间调制.

Cyriel M A Pennartz1, Marcel T G de Jeu, Nico P A Bos

  • 1Graduate School Neurosciences Amsterdam, Netherlands Institute for Brain Research. c.pennartz@nih.knaw.nl

Nature
|March 5, 2002
PubMed
概括
此摘要是机器生成的。

哺乳动物大脑钟在上神经核使用Ca2+电流来调节神经元的发射. 这种昼夜调制将内部分子节奏与大脑的日常时间信号联系起来.

更多相关视频

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells
11:56

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells

Published on: September 28, 2017

Manipulation of Rhythmic Food Intake in Mice Using a Custom-Made Feeding System
07:34

Manipulation of Rhythmic Food Intake in Mice Using a Custom-Made Feeding System

Published on: December 16, 2022

相关实验视频

Last Updated: May 10, 2026

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
06:53

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells
11:56

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells

Published on: September 28, 2017

Manipulation of Rhythmic Food Intake in Mice Using a Custom-Made Feeding System
07:34

Manipulation of Rhythmic Food Intake in Mice Using a Custom-Made Feeding System

Published on: December 16, 2022

科学领域:

  • 神经科学是一个神经科学.
  • 时间生物学 时间生物学
  • 分子生物学分子生物学

背景情况:

  • 哺乳动物大脑中的上神核 (SCN) 作为中央生物钟.
  • SCN神经元通过分子循环内在地产生昼夜节律.
  • 细胞内分子钟和神经元发射模式之间的联系仍然不清楚.

研究的目的:

  • 为了研究细胞内分子钟机制如何与等离子体膜相互作用.
  • 阐明离子导电在调节SCN神经元发射行为的作用.
  • 确定将分子节律与SCN神经元的昼夜发射率联系在一起的机制.

主要方法:

  • 超神经元的电生理记录.
  • 对 (Ca2+) 电流的研究.
  • 对膜电位振荡和尖峰生成的分析.

主要成果:

  • 在SCN神经元中证明了Ca2+电流的日间调制.
  • 确定了Ca2+电流作为自发膜电位振荡的关键贡献者.
  • 观察到,这些振荡发生在白天,并与动作潜能发射相结合.

结论:

  • 对Ca2+电流的昼夜调制是信号传导中的关键步骤.
  • 这个过程将细胞内分子时钟循环与神经元发射率的昼夜节律联系起来.
  • 电流在将分子计时转化为可观测的神经活动方面发挥着核心作用.