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在乙型肝炎病毒携带者中,动脉动脉样硬化的患病率增加
Nobukazu Ishizaka1, Yuko Ishizaka, Eiko Takahashi
1Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Japan. nobuishizka-tky@umin.ac.jp
乙型肝炎病毒表面抗原 (HBsAg) 的阳性与动脉斑块有关,这表明慢性乙型肝炎感染在动脉样硬化发展中的作用. 这项研究分析了超过4,600名个体的健康查数据.
科学领域:
- 心血管医学 心血管医学
- 传染性疾病 传染性疾病
- 肝病学 肝病学是一种肝病学.
背景情况:
- 新出现的证据将传染病原体与动脉样硬化发展联系起来.
- 乙型肝炎病毒 (HBV) 在心血管疾病中的潜在作用需要进一步调查.
研究的目的:
- 为了研究乙型肝炎病毒表面抗原 (HBsAg) 阳性和动脉样硬化存在之间的关联.
主要方法:
- 在4686名接受健康查的受试者中进行了横截面队列研究.
- 高分辨率的B模式頸動脈超聲波和HBsAg狀態評估.
- 经过调整以混风险因素的统计分析.
主要成果:
- 28%的受试者有动脉斑块;0.9%的受试者是HBsAg阳性 (HBV携带者).
- 阳性HBsAg显示出与心血管斑块的显著关联 (OR 1.58,P<0.05).
- 在调整为混因子 (OR 1.57,P<0.05) 之后,这种关联仍然显著.
结论:
- 慢性乙型肝炎感染可能在动脉动脉硬化病变中起作用.
- 阳性HBsAg是一种 carotid斑块的独立风险因素.
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