盐对二甲基硫酸盐小粒中的溶液交换的影响
Yahya Rharbi1, Mitchell A Winnik
1Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario, Canada M5S 3H6.
Journal of the American Chemical Society
|March 7, 2002
概括
化通过促进小细胞碎片化,加速SDS小细胞中的溶液交换. 这一由离子强度驱动的过程涉及亚粒细胞的形成和重构,这对于水不溶性溶液的转移至关重要.
科学领域:
- 物理化学 物理化学
- 合体和表面科学科学
- 超分子化学 超分子化学
背景情况:
- 二硫酸盐 (SDS) 微粒对于溶解不溶于水的化合物至关重要.
- 微粒内的溶液交换动态对各种化学和生物过程至关重要.
- 了解细胞稳定性和动态是控制溶液转移的关键.
研究的目的:
- 为了研究化对SDS微粒中溶液交换速率的影响.
- 为了阐明溶解物交换的机制,以一种不溶于水的含烯的甘油三.
- 为了将溶解物交换率与离子强度和细胞行为相关联.
主要方法:
- 用不溶于水的溶液 (含氨酸的甘油三) 制备SDS小粒溶液.
- 通过光光谱学监测溶液交换,测量脱剂 (I(E)) 和单体排放.
- 系统地改变化度以改变离子强度.
主要成果:
- 溶解物交换率 (k(obs)) 与离子强度显著增加,其次是类似于[Na(+) ](4) 的功率规律依赖性 (k(obs).
- 在添加盐后,排泄物排放呈指数级衰减,这表明溶解物重新分配.
- 速率取决于离子度,而不仅仅取决于空微粒度.
结论:
- 溶液交换是通过自发的小细胞片段化成小细胞发生的,其次是重构.
- 微粒碎片化是由大幅度的表面波动促进的,由头组排斥的 counterion 选增强.
- 拟议的模型解释了SDS微粒中依赖盐的溶液交换机制.
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