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头发针与替代β-氨酸结合聚胺的扩展DNA结合相比

Craig R Woods1, Takahiro Ishii, Bing Wu

  • 1Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.

Journal of the American Chemical Society
|March 7, 2002
PubMed
概括

研究人员使用阿尔法替代β-氨酸链接剂开发了新型聚胺. 一种特定的衍生物, (R) -α-甲基-β-氨酸,显示出强大的DNA结合亲和力和首选的针头形状,提供了一个新的针头链接器替代品.

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