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The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
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来自相邻区域的化学吸引剂的平衡反应决定了B细胞的位置.

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  • 1Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California San Francisco, 513 Parnassus Avenue, San Francisco, California 94143-0414, USA.

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与抗原接触的B淋巴细胞通过调节CCR7.7上升而移动到T区. 这种化学受体指导它们的迁移,对抗体反应和免疫细胞相互作用至关重要.

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科学领域:

  • 免疫学 免疫学 免疫学
  • 细胞生物学 细胞生物学
  • 分子生物学分子生物学

背景情况:

  • B 淋巴细胞在二级淋巴体器官中循环,检测抗原.
  • 抗原参与的B细胞在T区边界与T辅助细胞相互作用,这对于抗体反应至关重要.
  • 在抗原接触后,驱动B细胞迁移到T区的机制仍未定义.

研究的目的:

  • 阐明抗原接触后B细胞迁移到T区的分子机制.
  • 确定参与抗原驱动B细胞迁移的关键化学因受体和配体.

主要方法:

  • 对抗原参与B细胞上的化学因受体表达 (CCR7,CXCR5) 的分析.
  • 使用缺乏特定化学因子 (CCL19,CCL21) 或B细胞受体 (CCR7) 的淘汰赛小鼠进行的研究.
  • 以逆转录病毒为媒介的基因转移来评估CCR7和CXCR5表达在指导细胞迁移中的充分性.

主要成果:

  • 抗原参与增加B细胞表达CCR7,T区化学因子CCL19和CCL21的受体.
  • 在抗原接触时,B细胞向T区迁移取决于CCL19/CCL21化学因子和CCR7的表达.
  • 增加CCR7的表达足以将B细胞引导到T区,而CXCR5的过度表达可以取代这种迁移.

结论:

  • 化学因子受体响应 (CCR7和CXCR5) 的平衡决定了B细胞在淋巴体器官中的位置.
  • 在抗原接触时CCR7上调是驱动B细胞迁移到T区的主要机制.
  • 这项研究定义了抗原诱导的B细胞转移的分子基础,影响了我们对免疫反应的理解.