主要人类疹病毒8感染在免疫能力强的儿童
Massimo Andreoni1, Loredana Sarmati, Emanuele Nicastri
1Department of Public Health and Cellular Biology, University Tor Vergata, Via Montpellier 1, 00133 Rome, Italy. andreoni@uniroma2.it
JAMA
|March 12, 2002
概括
人类疹病毒8 (HHV-8) 在儿童的初级感染可能会导致发烧性斑点斑点皮疹. 唾液检测证实了HHV-8的DNA,这表明这是儿科患者的主要传播途径.
科学领域:
- 病毒学 病毒学
- 儿科 儿科 儿科
- 流行病学 流行病学
背景情况:
- 人类疹病毒8 (HHV-8) 已知会在免疫抑制成年人中引起卡波西肉瘤和淋巴增殖性疾病.
- 在免疫能力较强的个体,特别是儿童中,HHV-8的临床表现仍然在很大程度上是未知的.
研究的目的:
- 在免疫能力较强的儿童中调查症状原发性HHV-8感染.
- 在这个年龄组中确定与HHV-8感染相关的流行病学和病毒学因素.
主要方法:
- 一项前性队列研究在埃及亚历山大的一家儿科急诊室进行.
- 评估了86名1至4岁的儿童,他们患有不明原因的发烧性疾病.
- 血清分析和血液和唾液样本的PCR被用于检测HHV-8,同时收集风险因素数据.
主要成果:
- 41.9%的儿童为HHV-8呈阳性,其中38.9%的儿童检测到DNA,主要是在唾液中.
- 感染HHV-8与与多个儿童的密切接触和冬季的急诊室访问有显著的关联.
- 六名儿童表现出初级HHV-8感染的迹象,其中五例患有发烧性斑点斑块性皮疹.
结论:
- 免疫能力较强的儿童的初级HHV-8感染可能伴有发烧性斑点斑块性皮疹.
- 在唾液中检测到HHV-8的DNA,支持它作为儿童群体中主要传播途径的作用.
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