红细胞甲基叶酸和血同类作为静脉血栓栓塞的危险因素:一个匹配的病例控制研究
Isabelle Quéré1, Thomas V Perneger, Jacqueline Zittoun
1Internal Medicine Department University Hospital Saint Eloi, Montpellier, France. i-quere@chu-montpellier.fr
Lancet (London, England)
|March 13, 2002
概括
红细胞甲基叶酸盐水平可能有助于识别有风险发生静脉血栓栓塞的个体. 较低的甲基叶酸盐度与血液凝块的风险增加密切相关.
科学领域:
- 生物化学 生化学
- 遗传学 是一个遗传学.
- 临床医学 临床医学
背景情况:
- 适度的高血球囊血是静脉血栓塞栓症 (VTE) 的已知危险因素.
- 同型半氨酸与其复甲基化途径组件 (如甲基叶酸) 在静脉瘤风险中的特定作用仍然不清楚.
- 这项病例对照研究研究了关键的同类氨酸再甲基化途径组件与VTE风险之间的关系.
研究的目的:
- 分析同类氨酸再甲基化途径的主要成分与静脉血栓塞栓症风险之间的关联.
- 为了确定红细胞甲基叶酸盐水平是否可以作为VTE风险的生物标志物.
主要方法:
- 进行了一项病例对照研究,包括243名被诊断为深静脉血栓或肺栓塞的患者和年龄和性别匹配的对照.
- 测量包括血的同型半氨酸,氨酸和叶酸;红细胞总叶酸和甲基叶酸;和5,10-甲基基叶酸减少酶 (MTHFR) C677T基因型.
- 还评估了其他已确定的VTE风险因素.
主要成果:
- 在病例和对照人群之间,血类型半氨酸度有显著差异.
- 红细胞甲基叶酸盐水平与静脉瘤风险之间观察到一种强烈的,度依赖的关联,随着甲基叶酸盐水平的下降,几率比率增加.
- 较低的甲氨酸度,高体重指数,癌症史,VTE家族史,口服避孕药的使用和V Leiden因子突变也独立地与增加的VTE风险有关.
- 红细胞甲基叶酸和静脉瘤风险之间的关联受MTHFR C677T基因型的影响.
结论:
- 测量红细胞甲基叶酸盐度可以帮助识别患有静脉血栓塞栓症风险较高的人.
- 这一发现突显了评估VTE风险分层的甲基叶酸盐水平的潜在临床有用性.
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