没有感官输入的中央模式发生器的胚胎组件.
Maximiliano L Suster1, Michael Bate
1Department of Zoology, University of Cambridge, UK. msuster@credit.erin.utoronto.ca
Nature
|March 15, 2002
概括
感官输入对于发展Drosophila.基本爬行模式并不重要. 然而,感官信息对于正确的前进运动至关重要,因为缺少它会导致反向运动.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 发动机控制器的控制器
背景情况:
- 运动依赖于将感官数据与中枢神经系统活动相结合.
- 中央模式生成器产生独立于感官反的节奏电机输出.
- 感官信息微调运动模式,以实时调整运动.
研究的目的:
- 研究传感输入对于发动机电路发展的必要性.
- 确定传感系统在发育过程中的运动模式组合中的作用.
- 分析感官剥夺对Drosophila围静运动的影响.
主要方法:
- 在Drosophila胚胎和幼虫中消除感官功能和结构.
- 分析围静运动模式的发展.
- 记录和比较虚构的运动节奏,有和没有感官输入.
主要成果:
- 围静爬行的基本电路在没有感官输入的情况下发展.
- 没有感官输入导致运动极性失调.
- 当感官输入缺少时,向后的围静电波会在前方围静电波上占主导地位.
结论:
- 围静运动的内在神经回路是独立于感官体验而建立的.
- 传感系统对于适当的集成和运动方向控制至关重要.
- 发育过程中的感官剥夺损害了产生协调前进运动的能力.
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