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Updated: May 7, 2026

SorLA and CLC:CLF-1-dependent Downregulation of CNTFRα as Demonstrated by Western Blotting, Inhibition of Lysosomal Enzymes, and Immunocytochemistry
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SorLA and CLC:CLF-1-dependent Downregulation of CNTFRα as Demonstrated by Western Blotting, Inhibition of Lysosomal Enzymes, and Immunocytochemistry

Published on: January 6, 2017

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内素-CIN85-Cbl复合体调节了c-Met的依赖于连接体的下调调

Annalisa Petrelli1, Giorgio F Gilestro, Stefania Lanzardo

  • 1CNR-CIOS and Department of Genetics, Biology and Biochemistry, University of Torino, 10126 Torino, Italy.

Nature
|March 15, 2002
PubMed
概括

一个新发现的综合体涉及内啡,CIN85和Cbl调节肝细胞生长因子 (HGF) 受体 (Met) 内化. 这一发现澄清了HGF受体信号传递和内细胞分裂机制.

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Receptor-mediated Endocytosis

Overview
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Receptor-mediated Endocytosis

Receptor-mediated endocytosis is when bulk amounts of specific molecules are imported into a cell after binding to cell surface receptors. The molecules bound to these receptors are taken into the cell through inward folding of the cell surface membrane, which is eventually pinched off into a vesicle within the cell. Structural proteins, such as clathrin, coat the budding vesicle.
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