基于导管的内肌心内膜注射与实时磁共振成像
Robert J Lederman1, Michael A Guttman, Dana C Peters
1Cardiovascular Branch, Division of Intramural Research, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Md 20892-1061, USA. Lederman@nih.gov
Circulation
|March 20, 2002
概括
这项研究表明,实时核磁共振成像 (rtMRI) 能够在左心室 (LV) 壁中进行精确的,有针对性的注射. 这种新的方法显示了皮肤内肌心药物输送的可行性.
科学领域:
- 心血管成像 - 心血管成像
- 干预心脏病学 干预心脏病学
- 生物医学工程 生物医学工程
背景情况:
- 使用实时磁共振成像 (rtMRI) 评估向左心室 (LV) 壁面注射的可行性.
研究的目的:
- 评估rtMRI用于指导皮肤内肌心内膜注射的疗效.
- 为了证明药物输送的LV壁内精确的3D定位.
主要方法:
- 一台1.5TMRI扫描仪的定制,配备快速重建引擎,输导导管-接收器线圈 (GCC) 和MRI兼容的针.
- 使用商业实时成像软件用于导管导航和以每秒4的速度可视化.
- 在直接的rtMRI指导下,对猪进行了50多次内心肌内注射.
主要成果:
- 在rtMRI指导下成功穿越大动脉并进入左心室腔.
- 易于可视化的GCC和针头注射器,可以访问所有心肌段.
- 通过第一代原型,在内心肌内注射中取得了81%的成功率.
结论:
- 透皮内肌心药物输送是可行的使用rtMRI.
- rtMRI允许精确的3D注射在LV壁内进行定位.
- 这种技术对针对性心脏治疗具有前景.
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