在腹腔疾病中发生非霍奇金淋巴瘤的风险
Carlo Catassi1, Elisabetta Fabiani, Giovanni Corrao
1University of Maryland, Division of Pediatric Gastroenterology and Nutrition, 22 S Greene St, N5W70/Box 140, Baltimore, MD 21201, USA. catassi@tin.it
JAMA
|March 21, 2002
概括
患有乳病的人面临患非霍奇金淋巴瘤,特别是T细胞和肠道淋巴瘤的风险较高. 然而,这种增加的风险并不意味着广泛的早期查乳病.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 病是一种普遍存在的终身自身免疫性疾病.
- 非霍奇金淋巴瘤 (NHL) 是一种被公认的乳病的潜在并发症.
研究的目的:
- 为了确定患有腹腔疾病的个体患有任何类型的非霍奇金淋巴瘤的定量风险.
主要方法:
- 从1996年1月到1999年12月,在意大利进行了一项多中心病例控制研究.
- 这些病例包括20岁以上被诊断患有非霍奇金淋巴瘤 (NHL) 的患者.
- 对照组包括来自普通人口的健康成年人,通过抗内分泌抗体检测诊断出患有乳病.
主要成果:
- 在0.92%的淋巴瘤患者和0.42%的对照人群中发现了乳性疾病.
- 与腹腔疾病相关的NHL调整后几率比为3.1,对于肠道淋巴瘤 (16.9) 和T细胞淋巴瘤 (19.2) 显著更高.
- 根据年龄和性别调整后,NHL的总人口风险为0.63%.
结论:
- 结核病与非霍奇金淋巴瘤的更高风险有关,特别是T细胞和肠道局部化类型.
- 尽管存在这种关联,但风险大小并不支持为预防淋巴瘤而进行大规模查.
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