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Updated: May 5, 2026

A TIRF Microscopy Technique for Real-time, Simultaneous Imaging of the TCR and its Associated Signaling Proteins
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Published on: March 22, 2012

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在TNF-RII和c-IAP1的介导下,TRAF2的泛化和降解发生

Xiaoming Li1, Yili Yang, Jonathan D Ashwell

  • 1Laboratory of Immune Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Nature
|March 22, 2002
PubMed
概括

结合TNF-RII的瘤坏死因子-α (TNF-α) 触发了通过c-IAP1 E3结合酶活动的TRAF2无化和降解. 这种机制增强了TNF诱导的亡,揭示了c-IAP1在TNF信号通路中的关键作用.

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