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一个RNA活性位点的表征:Diels-Alderase ribozyme及其基质和产物之间的相互作用

Friedrich Stuhlmann1, Andres Jäschke

  • 1Department of Biology, Chemistry and Pharmacy, Institute of Chemistry, Free University of Berlin, Thielallee 63, D-14195 Berlin, Germany.

Journal of the American Chemical Society
|March 28, 2002
PubMed
概括

迪尔斯-阿尔德拉酶 ribozymes 催化碳-碳键的形成. 化学分析揭示了RNA-diene堆叠相互作用控制基质结合和立体选择反应,突出了复杂的 ribozyme 活性位点控制.

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