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通过斯芬戈-1-酸盐受体agonists改变淋巴细胞的贩运

Suzanne Mandala1, Richard Hajdu, James Bergstrom

  • 1Department of Immunology and Rheumatology, Merck Research Laboratories, Post Office Box 2000, Rahway, NJ 07065, USA.

Science (New York, N.Y.)
|March 30, 2002
PubMed
概括

斯芬戈辛-1-酸盐 (S1P) 和FTY720代谢物通过激活S1P受体改变了淋巴细胞的流通. 这导致淋巴结中的淋巴细胞封存,导致淋巴缺血和潜在的治疗性免疫抑制.

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