在绝经后妇女的雌激素替代疗法期间,他类药物减弱了C反应性蛋白的增加
Kwang Kon Koh1, William H Schenke, Myron A Waclawiw
1Gachon Medical College, Inchon, South Korea.
Circulation
|April 3, 2002
概括
在绝经后的妇女中,将他类药物与口服雌激素结合使用可能会减少有害的炎症. 这种他类激素组合疗法减弱了单独使用雌激素所见的C-反应蛋白 (CRP) 水平的增加.
科学领域:
- 心血管医学 心血管医学
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 已知HMG-CoA减小酶抑制剂 (他类药物) 疗法可降低心血管风险,可能通过降低低C反应蛋白 (CRP) 水平所表明的动脉炎症.
- 口服雌激素可以增加绝经后妇女的CRP,造成炎症和血栓形成的风险,这可能会抵消心血管的益处.
- 这项研究调查了与他类药物联合使用是否可以改变对CRP的雌激素作用.
研究的目的:
- 确定他类药物治疗是否可以缓解口服雌激素对绝经后妇女C反应性蛋白 (CRP) 水平的炎症影响.
- 评估结合合马雌激素 (CEEs) 与simvastatin对CRP水平的影响.
主要方法:
- 这是一项双盲三期交叉研究,涉及28名绝经后妇女.
- 参与者每天接受0.625毫克的结合性马类雌激素 (CEEs),10毫克的simvastatin或6周的组合,分隔6周的洗间隔.
- 测量了CRP水平的变化,并在治疗组之间进行了比较.
主要成果:
- 单单CEE就显著增加了中位数CRP水平 (从0.27到0.46毫克/分升).
- 单独使用西姆瓦斯塔丁,CRP水平略有下降 (从0.29至0.28毫克/分升).
- 组合疗法增加了CRP (从0.28到0.36毫克/分升),但这种增加明显小于 (29%) 单独使用CEE (70%).
结论:
- 将他类药物与雌激素治疗结合起来,可能会减轻雌激素在绝经后妇女身上潜在的有害炎症影响.
- 这种组合可能有助于最大限度地减少心血管风险的好处.
- 这项研究表明,使用激素治疗的绝经后妇女管理心血管风险的潜在策略.
相关概念视频
Hormonal Regulation
37.6K
Hormones regulate a significant portion of digestion through activation of the neuroendocrine system. The neuroendocrine system of digestion contains many different hormones all with multiple functions that are both, directly and indirectly, involved in digestion.
37.6K
Drugs for Peptic Ulcer Disease: Prostaglandin Analogs as Mucosal Protective Agents
1.7K
The gastric mucosa produces prostaglandins E2 (PGE2) and prostacyclin (PGI2), crucial in maintaining gastric health. They exert cytoprotective effects, including increasing bicarbonate secretion, releasing protective mucin, reducing gastric acid output, and preventing harmful vasoconstriction. These effects are mediated through various receptors, such as EP1, EP2, EP3, and EP4.
Non-steroidal anti-inflammatory drugs (NSAIDs) can induce peptic ulcers by inhibiting cyclooxygenase, decreasing...
Non-steroidal anti-inflammatory drugs (NSAIDs) can induce peptic ulcers by inhibiting cyclooxygenase, decreasing...
1.7K
Drugs for Treatment of Constipation-Predominant IBS
1.4K
Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
1.4K
Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists
927
5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
927
Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists
820
Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy. SP binds and activates...
820
Intestinal Phase of Digestion
10.1K
The intestinal phase of digestion is the third and final stage of the digestive process, occurring after the cephalic and gastric phases. It begins when chyme, a partially digested mixture of food and digestive enzymes, enters the small intestine from the stomach. This phase is crucial for nutrient absorption and involves complex hormonal and enzymatic interactions.
The arrival of the chyme in the small intestine distends the duodenum, which triggers the enterogastric reflex. This distension...
The arrival of the chyme in the small intestine distends the duodenum, which triggers the enterogastric reflex. This distension...
10.1K


