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Updated: Jun 16, 2026

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice
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Published on: August 23, 2019

DNMT1和DNMT3b合作使人类癌细胞中的基因沉默

Ina Rhee1, Kurtis E Bachman, Ben Ho Park

  • 1The Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA.

Nature
|April 5, 2002
PubMed
概括

人类癌细胞依赖两个关键酶,DNA甲基转移酶1 (DNMT1) 和DNMT3B,用于DNA甲基化和基因沉默. 破坏两者都会显著降低甲基化,影响癌细胞生长.

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