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大型抑郁症中Hypericum perforatum (圣约翰草) 的作用:一项随机对照试验
JAMA
|April 10, 2002
概括
这项研究发现,Hypericum perforatum (圣约翰草) 在治疗严重抑郁症方面并不比安慰剂更有效. 塞特拉林在主要结局中也没有与安慰剂显著差异.
科学领域:
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
- 临床研究 临床研究
背景情况:
- Hypericum perforatum (圣约翰草) 通常用于抑郁症.
- 它在重度抑郁症治疗中的有效性需要进一步的科学验证.
研究的目的:
- 评估标准化Hypericum perforatum提取物 (LI-160) 在患有重度抑郁症患者的疗效和安全性.
- 为了比较它的效果与安慰剂和塞特拉林.
主要方法:
- 进行了一项双盲,随机,安慰剂对照试验,包括340名被诊断患有严重抑郁症的成人门诊患者.
- 参与者接受了Hypericum perforatum,安慰剂或塞特拉林治疗8周,根据反应调整剂量.
- 主要结果措施包括汉密尔顿抑郁量表 (HAM-D) 总得分和完全反应率的变化.
主要成果:
- 与安慰剂相比,Hypericum perforatum和塞特拉林在降低HAM-D得分方面都没有显示出统计学上显著的差异.
- 所有组的应答率都相似:安慰剂组为31.9%,穿孔为23.9%,塞特拉林为24.8%.
- 塞特拉林在临床全球印象 (CGI) 尺度上显著改善,这是次要的结果,但治疗方法之间的不良事件概况有所不同.
结论:
- 该研究没有发现证据支持Hypericum perforatum在治疗中度重度重度抑郁症的疗效.
- 缺乏观察到的疗效可能归因于试验的测试灵敏度,尽管缺乏任何疗效趋势是值得注意的.
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