Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Perspective on a challenge: Predicting the photochemistry of cyclobutanone.

The Journal of chemical physics·2026
Same author

Structural insights into spectral tuning and retinal exchange in cone visual pigments.

Science (New York, N.Y.)·2026
Same author

Metal-decorated graphdiyne nanocarriers for favipiravir delivery: a DFT investigation.

Nanoscale advances·2026
Same author

Rational design of hammerhead ribozymes as CD93 silencing tools for vascular diseases.

Molecular therapy. Nucleic acids·2026
Same author

In-hospital outcomes of valve-in-valve vs. native valve transcatheter aortic valve implantation in Brazil: A propensity-matched analysis.

International journal of cardiology·2026
Same author

A Twist in Electronic Relaxation of Pyrimidine Nucleosides and Nucleotides: Impact of C5 Methylation on Nonadiabatic Transition and Photohydration Damage.

Journal of the American Chemical Society·2026

相关实验视频

Updated: Jul 6, 2026

Genetic Barcoding with Fluorescent Proteins for Multiplexed Applications
13:14

Genetic Barcoding with Fluorescent Proteins for Multiplexed Applications

Published on: April 14, 2015

对自由和锁定视网膜染色体的"可调"光异构化选择性的反应路径分析.

Luca De Vico1, Christopher S Page, Marco Garavelli

  • 1Dipartimento di Chimica, Università di Siena, via Aldo Moro, Siena, I-53100 Italy.

Journal of the American Chemical Society
|April 11, 2002
PubMed
概括

视网膜染色体具有多个激发状态异构化通路,主要在双键9,11,和13处. 计算显示位置11是受欢迎的,有助于理解生物系统中的染色体行为.

科学领域:

  • 计算化学的计算化学
  • 摄影化学的使用.
  • 分子生物物理学 分子生物物理学

背景情况:

  • 视网膜质子化希夫基是视觉和信号蛋白中的关键染色体.
  • 了解它们的光异构化动态是阐明生物功能的关键.

研究的目的:

  • 为了研究视网膜染色体中竞争激发状态异构化途径.
  • 为了合理化在各种环境中观察到的兴奋状态寿命.

主要方法:

  • 多配置二次扰动理论 (CASSCF).
  • 反应路径映射反应路径映射.
  • 对形交叉面能量表面的分析.

主要成果:

  • 确定了至少三个竞争激发状态双键异构化路径 (位置9,11,13).
  • 发现的异构化障碍有利于在位置11的双键.
  • 在bacteriorhodopsin中的合理化光异构化作为催化和抑制的组合.
  • 对不同的异构化路径观察到不同的能量表面结构.

结论:

  • 计算洞察力解释了视网膜染色体兴奋状态寿命.

更多相关视频

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development
09:32

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development

Published on: June 15, 2017

Automated Two-dimensional Spatiotemporal Analysis of Mobile Single-molecule FRET Probes
08:26

Automated Two-dimensional Spatiotemporal Analysis of Mobile Single-molecule FRET Probes

Published on: November 23, 2021

相关实验视频

Last Updated: Jul 6, 2026

Genetic Barcoding with Fluorescent Proteins for Multiplexed Applications
13:14

Genetic Barcoding with Fluorescent Proteins for Multiplexed Applications

Published on: April 14, 2015

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development
09:32

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development

Published on: June 15, 2017

Automated Two-dimensional Spatiotemporal Analysis of Mobile Single-molecule FRET Probes
08:26

Automated Two-dimensional Spatiotemporal Analysis of Mobile Single-molecule FRET Probes

Published on: November 23, 2021

  • 光异构化途径受到特定环境相互作用的影响,如在bacteriorhodopsin中所见.
  • 能量表面的结构差异与明显的光异构化行为相关.