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相关概念视频

Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
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Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
Cancer Prevention02:59

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Mutagenicity and Carcinogenicity01:25

Mutagenicity and Carcinogenicity

Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
Disorders of the Female Reproductive System01:24

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The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
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相关实验视频

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Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats
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口服避孕药对感染人类乳头瘤病毒的妇女子宫癌风险的影响:IARC多中心病例控制研究

Victor Moreno1, F Xavier Bosch, Nubia Muñoz

  • 1Epidemiology and Cancer Registry Service, Catalan Institute of Oncology, Hospital Duran i Reynals, L'Hospitalet de Llobregat, Barcelona, Spain. v.moreno@ico.scs.es

Lancet (London, England)
|April 12, 2002
PubMed
概括

长期使用口服避孕药显著增加了HPV阳性女性的宫癌风险,可能高达四倍. 由于这种风险增加,建议增加长期使用者的查.

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科学领域:

  • 妇科 妇科医生 妇科
  • 在瘤学瘤学.
  • 流行病学 流行病学

背景情况:

  • 口服避孕药的使用是宫癌的已知危险因素.
  • 人类乳头瘤病毒 (HPV) 在这种关联中的作用经常被忽视.
  • 这项研究调查了HPV阳性女性口服避孕药的使用情况.

研究的目的:

  • 评估口服避孕药使用对宫癌风险的影响.
  • 为了特别评估感染HPVDNA的妇女的这种风险.

主要方法:

  • 从10个病例控制研究 (8种侵袭性宫癌,2种 in situ癌症) 的数据汇总.
  • 通过个人访谈评估口服避孕药的使用情况.
  • 调整了混因子的后勤回归模型,以估计赔率比率.

主要成果:

  • 94%的侵袭性宫癌和72%的现场癌症病例是HPVDNA阳性的.
  • 5-9年使用口服避孕药的几率比为2.82.
  • 使用10年或更长时间会显著增加风险 (OR4.03).

结论:

  • 长期使用口服避孕药 (5年以上) 是HPV阳性女性宫癌的辅因子.
  • 长期使用口服避孕药时,风险可能增加多达四倍.
  • 建议长期使用口服避孕药的人进行有针对性的宫查,特别是在不知道HPV状况的情况下.