在宫癌中平价和人类乳头瘤病毒的作用:IARC多中心病例控制研究
Nubia Muñoz1, Silvia Franceschi, Cristina Bosetti
1Unit of Field and Intervention Studies, International Agency for Research on Cancer, 150 Cours Albert Thomas, F-69372, Cédex 08, Lyon, France. munoz@iarc.fr
Lancet (London, England)
|April 12, 2002
概括
高平价或多次怀孕显著增加了患有人类乳头瘤病毒 (HPV) 感染的女性状细胞子宫癌的风险. 这一发现可能有助于解释最近宫癌率的下降.
科学领域:
- 妇科 妇科 妇科 妇科
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 从历史上看,高平价与增加子宫癌风险有关.
- 以前的研究没有充分考虑人类乳头瘤病毒 (HPV) 的重要作用.
- 这项研究侧重于影响HPV向子宫癌进展的生殖因素.
研究的目的:
- 调查高平价与宫癌风险之间的关联,特别是在HPV阳性女性中.
- 澄清生殖史在状细胞宫癌发展中的作用.
- 评估平价是否影响腺癌或腺癌的风险.
主要方法:
- 对八项针对侵袭性宫癌 (ICC) 的病例控制研究和两项针对in-situ癌 (ISC) 的研究进行了综合分析.
- 包括1465个ICC,211个ISC,124个腺癌/腺性ICC病例和255个HPV阳性对照.
- 使用无条件的多重物流回归,调整混因素,以计算聚合赔率比率.
主要成果:
- 研究人员发现,满期怀孕的数量与状细胞子宫癌风险之间存在直接关联.
- 与无孕妇女相比,有七次或更多次满期怀孕的妇女的几率比率为3.8 (95% CI 2.7-5.5).
- 没有观察到平价与腺癌或腺癌的风险之间存在显著的关联.
结论:
- 高平价是HPV阳性女性状细胞宫癌的重要危险因素.
- 观察到的关联突出显示了生殖史和HPV在宫癌发生过程中的相互作用.
- 平均平价的潜在下降可能有助于全球观察到的宫癌发病率的减少.
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