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Olfaction01:25

Olfaction

The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
Background and Environment Affect Phenotype02:27

Background and Environment Affect Phenotype

Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
Physiology of Smell and Olfactory Pathway01:20

Physiology of Smell and Olfactory Pathway

Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...

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相关实验视频

Updated: Jun 30, 2026

Imaging Pheromone Sensing in a Mouse Vomeronasal Acute Tissue Slice Preparation
09:31

Imaging Pheromone Sensing in a Mouse Vomeronasal Acute Tissue Slice Preparation

Published on: December 6, 2011

费洛蒙,鼻功能和性别特异性的行为.

Eric B Keverne1

  • 1Sub-Department of Animal Behaviour, University of Cambridge, Madingley, CB3 8AA, Cambridge, United Kingdom. ebk10@cus.cam.ac.uk

Cell
|April 17, 2002
PubMed
概括
此摘要是机器生成的。

没有TRP2离子通道的小鼠表现出不同的行为,揭示了鼻器官在性别特定的社会相互作用和繁殖中的关键作用.

更多相关视频

Imaging Neuronal Responses in Slice Preparations of Vomeronasal Organ Expressing a Genetically Encoded Calcium Sensor
11:26

Imaging Neuronal Responses in Slice Preparations of Vomeronasal Organ Expressing a Genetically Encoded Calcium Sensor

Published on: December 6, 2011

In-depth Physiological Analysis of Defined Cell Populations in Acute Tissue Slices of the Mouse Vomeronasal Organ
10:11

In-depth Physiological Analysis of Defined Cell Populations in Acute Tissue Slices of the Mouse Vomeronasal Organ

Published on: September 10, 2016

相关实验视频

Last Updated: Jun 30, 2026

Imaging Pheromone Sensing in a Mouse Vomeronasal Acute Tissue Slice Preparation
09:31

Imaging Pheromone Sensing in a Mouse Vomeronasal Acute Tissue Slice Preparation

Published on: December 6, 2011

Imaging Neuronal Responses in Slice Preparations of Vomeronasal Organ Expressing a Genetically Encoded Calcium Sensor
11:26

Imaging Neuronal Responses in Slice Preparations of Vomeronasal Organ Expressing a Genetically Encoded Calcium Sensor

Published on: December 6, 2011

In-depth Physiological Analysis of Defined Cell Populations in Acute Tissue Slices of the Mouse Vomeronasal Organ
10:11

In-depth Physiological Analysis of Defined Cell Populations in Acute Tissue Slices of the Mouse Vomeronasal Organ

Published on: September 10, 2016

科学领域:

  • 神经科学是一个神经科学.
  • 行为生物学 行为生物学
  • 感官系统 感官系统

背景情况:

  • 吐口鼻子器官 (VNO) 是一种感觉结构,涉及到检测激素.
  • TRP2离子通道在VNO中表达,对于感官传导至关重要.

研究的目的:

  • 研究TRP2离子通道在鼻器官功能中的作用.
  • 阐明VNO和TRP2对小鼠性别特异性性行为的贡献.

主要方法:

  • 缺乏TRP2离子通道的小鼠的行为分析 (TRP2淘汰赛小鼠).
  • 在受控实验环境中评估社会和性行为.

主要成果:

  • 与野生类型对照相比,TRP2淘汰小鼠表现出明显改变的性别特异性性行为.
  • 这些行为缺陷凸显了VNO介导的感官输入在调节生殖行为的关键作用.

结论:

  • TRP2离子通道对于正常的口腔鼻腔器官功能至关重要.
  • 由TRP2介导的鼻器官信号传递对于精确执行特定性别的性行为是不可或缺的.