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Updated: Jun 26, 2026

Reconstitution Of β-catenin Degradation In Xenopus Egg Extract
09:41

Reconstitution Of β-catenin Degradation In Xenopus Egg Extract

Published on: June 18, 2014

通过双酶机制控制β-catenin的酸化/降解

Chunming Liu1, Yiming Li, Mikhail Semenov

  • 1Division of Neuroscience, Children's Hospital, Department of Neurology, Harvard Medical School, Boston, MA 02115, USA.

Cell
|April 17, 2002
PubMed
概括

氨酸激酶Ialpha (CKIalpha) 为β-catenin提供了由糖原合成酶激酶-3 (GSK-3) 降解的原始. 这一发现揭示了Wnt信号传递中明显的酸化步骤,影响了发育和癌症等疾病.

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