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Updated: Jul 19, 2026

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从丑的鱼到征服死亡:JJR麦克劳德的鱼类胰岛素研究,1922年至1924年

James R Wright1

  • 1Department of Pathology, IWK Health Centre and Dalhousie University, Halifax, Nova Scotia, Canada.

Lancet (London, England)
|April 17, 2002
PubMed
概括

鱼类胰岛素为早期胰岛素短缺提供了潜在的解决方案,但面临着后勤挑战. 畜牧业的胰岛素生产有所改善,导致鱼类胰岛素研究被放弃.

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Insulin: Biosynthesis, Chemistry, and Preparation01:25

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The endoplasmic reticulum (ER) of pancreatic β-cells synthesizes preproinsulin, which consists of a signal peptide, A and B chains, and a C-peptide. Preproinsulin is then cleaved and folded into proinsulin, which translocates to the Golgi apparatus for sorting and packaging into secretory granules. In these granules, enzymatic clipping generates insulin and C-peptide.
Damage or functional impairment of β-cells inhibits insulin production, leading to diabetes. Diabetes treatment primarily uses...