过敏,寄生虫,以及卫生假设
Maria Yazdanbakhsh1, Peter G Kremsner, Ronald van Ree
1Department of Parasitology, Leiden University Medical Center, Leiden, Netherlands. M.Yazdanbakhsh@LUMC.NL
概括
持久性感染,如虫感染,可以通过诱导抗炎反应来预防过敏. 这挑战了儿童感染较少导致过敏患病率增加的观点.
科学领域:
- 免疫学 免疫学 免疫学
- 流行病学 流行病学
背景情况:
- 在工业化国家,过敏性疾病的增加,往往与儿童感染的减少有关.
- 卫生假设表明,减少微生物暴露导致不平衡的T辅助1 (TH1) 和T辅助2 (TH2) 细胞反应,有利于过敏.
研究的目的:
- 调查持续性感染和过敏性疾病之间的关系.
- 探索抗炎细胞因子在调节对感染和过敏的免疫反应中的作用.
主要方法:
- 对过敏患病率的免疫学解释的审查.
- 对感染和过敏性疾病的流行病学数据的分析.
- 检查细胞因子概况,包括因特鲁金-10,作为对虫感染的反应.
主要成果:
- 减少感染增加过敏的概念受到TH1自身免疫性疾病的增加和与TH2歪曲虫感染缺乏过敏相关性的挑战.
- 长期的虫感染与抗炎性细胞因子的升高有关,如互乐金-10.
- 这些细胞因子与过敏患病率呈反向相关性.
结论:
- 持续的免疫挑战,如虫感染,诱导一个强大的抗炎调节网络.
- 这个网络为许多感染和过敏疾病之间观察到的反向关联提供了一个统一的解释.
- 这些发现表明感染,免疫调节和过敏发展之间的相互作用比以前理解的要复杂得多.
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