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相关概念视频

Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
Concepts of Health and Illness01:29

Concepts of Health and Illness

Health is a condition of the body, mind, and spirit where an individual remains free from illness. Similarly, wellness is an active state, including living a lifestyle that promotes physical, mental, and emotional health. Physical health is critical for the overall well-being and can be affected by lifestyle, activity level, diet, and behavior. The highest attainable standard of health is a fundamental and universal human right. Consider Lisa, a fifteen-year-old born with congenital...
Factors Affecting Illness01:18

Factors Affecting Illness

When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness, disability,...
Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic01:26

Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic

Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies. Common...
Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care01:30

Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care

A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...
Infectious Diseases and Their Occurrence01:28

Infectious Diseases and Their Occurrence

Infectious diseases appear in populations through various transmission patterns, influenced by pathogen characteristics, population immunity, environmental conditions, and social behavior. Understanding these patterns is essential for effective public health surveillance and intervention. These categories—sporadic, outbreak, epidemic, pandemic, and endemic—help frame the nature and scope of disease events.Sporadic diseases occur irregularly and infrequently, without a predictable temporal or...

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相关实验视频

Updated: Jul 20, 2026

Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models
09:54

Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models

Published on: December 3, 2019

复杂疾病和新的临床科学.

Jonathan Rees1

  • 1Systems Group, Department of Dermatology, University of Edinburgh, The Lauriston Building, Lauriston Place, Edinburgh EH3 9YW, UK. jonathan.rees@ed.ac.uk

Science (New York, N.Y.)
|April 27, 2002
PubMed
概括

医学研究过于关注基因,忽视了以患者为中心的研究. 这种转变阻碍了临床进展,表明对医学进步的理解有缺陷.

科学领域:

  • 医学研究方法论医学研究方法论.
  • 临床发现范式的临床发现范式

背景情况:

  • 目前的医学研究严重以基因为中心.
  • 以患者为导向的研究和临床发现已经下降.
  • 这些趋势可能相互关联.

研究的目的:

  • 提出以种族为中心的研究的主导地位和以患者为导向的研究的下降是相互依存的.
  • 挑战关于临床进步如何发生的普遍观点.

主要方法:

  • 对当前医学研究趋势的概念分析.
  • 临床发现中的种族中心观点的批评.

主要成果:

  • 目前的种族中心方法是临床进步的一个不准确的模型.
  • 以患者为导向的研究的下降与这种错误的种族中心观点有关.

结论:

  • 医学研究需要改变范式,重新强调以患者为导向的发现.
  • 重新思考临床进步的驱动因素对于未来的医学进步至关重要.

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