相关实验视频
Updated: Jul 1, 2026

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Molecular Evolution of the Tre Recombinase
Published on: May 29, 2008
TREX是一种保存的复杂合转录与信使RNA出口
Katja Strässer1, Seiji Masuda, Paul Mason
1BZH, University of Heidelberg, Im Neuenheimer Feld 328, D-69120 Heidelberg, Germany.
Nature
|April 30, 2002
概括
包含酵母蛋白Yira1和Sub2以及它们的甲基动物对应物Aly和UAP56的TREX复合体,链接转录和mRNA输出. 这种保存复合体在转录过程中被招募到激活的基因中.
科学领域:
- 分子生物学分子生物学
- 细胞生物学 细胞生物学
- 遗传学 是一个遗传学.
背景情况:
- 传递 RNA (mRNA) 输出和拼接是关键的细胞过程.
- 酵母蛋白Yira1和Sub2是关键的mRNA出口因子,与保存的甲基动物同类物Aly和UAP56.
- 这些因素连接了拼接和mRNA出口机械.
研究的目的:
- 调查 Yra1 和 Sub2 与 THO 综合体的关联.
- 定义一个连接转录和mRNA出口的保存复合体.
- 阐明这个复合体在基因表达中的作用.
主要方法:
- 生物化学测试以确定蛋白质的关联.
- 基因相互作用研究.
- 在酵母和甲基动物系统中分析RNA出口.
主要成果:
- Yra1和Sub2在经体测量上与酵母THO复合体有关.
- 遗传相互作用证实了 Yra1,Sub2 和 THO 组件之间的功能联系.
- 艾利和UAP56与人类的THO复合体对应物相结合.
- 保存的TREX复合体被招募到激活的基因中,并与RNA聚合酶II一起传播.
结论:
- 定义了一个保存的TREX (转录/出口) 复合体,包括Yra1/Aly,Sub2/UAP56和THO复合体组件.
- 在合转录与mRNA出口方面,TREX复合体起着保留的作用.
- 这个复合体被招募到积极转录的基因中,并与RNA聚合酶II一起移动.
相关概念视频
Transcription
Overview
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds...
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds...
Overview of Transposition and Recombination
Transposons make up a significant part of genomes of various organisms. Therefore, it is believed that transposition played a major evolutionary role in speciation by changing genome sizes and modifying gene expression patterns. For example, in bacteria, transposition can lead to conferring antibiotic resistance. Movement of transposable elements within the genetic pool of pathogenic bacteria can aid in transfer of antibiotic-resistant genetic elements. In eukaryotes, transposons can carry out...
LTR Retrotransposons
LTR retrotransposons are class I transposable elements with long terminal repeats flanking an internal coding region. These elements are less abundant in mammals compared to other class I transposable elements. About 8 percent of human genomic DNA comprises LTR retrotransposons. Some of the common examples of LTR retrotransposons are Ty elements in yeast and Copia elements in Drosophila.
The internal coding region of LTR retrotransposons and their mechanism of transposition closely resembles a...
The internal coding region of LTR retrotransposons and their mechanism of transposition closely resembles a...
Transfer RNA Synthesis
One of the unique features of tRNA is the presence of modified bases. In some tRNAs, modified bases account for nearly 20% of the total bases in the molecule. Altogether, these unusual bases protect the tRNA from enzymatic degradation by RNases.
Each of these chemical modifications is carried by a specific enzyme, post-transcription. All of these enzymes have unique base and site-specificity. Methylation, the most common chemical modification, is carried by at least nine different enzymes, with...
Each of these chemical modifications is carried by a specific enzyme, post-transcription. All of these enzymes have unique base and site-specificity. Methylation, the most common chemical modification, is carried by at least nine different enzymes, with...
Transcription
Transcription is the synthesis of RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in correctly synthesizing messenger RNA (mRNA). Transcriptional regulation is responsible for the differentiation of different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds of RNA Molecules
In eukaryotes,...
Transcription Can Produce Different Kinds of RNA Molecules
In eukaryotes,...
Transfer RNA Synthesis
One of the unique features of tRNA is the presence of modified bases. In some tRNAs, modified bases account for nearly 20% of the total bases in the molecule. Altogether, these unusual bases protect the tRNA from enzymatic degradation by RNases.
Each of these chemical modifications is carried by a specific enzyme, post-transcription. All of these enzymes have unique base and site-specificity. Methylation, the most common chemical modification, is carried by at least nine different enzymes, with...
Each of these chemical modifications is carried by a specific enzyme, post-transcription. All of these enzymes have unique base and site-specificity. Methylation, the most common chemical modification, is carried by at least nine different enzymes, with...

