突发冠状动脉死亡中C反应蛋白值升高和动脉样硬化:与不同病理学相关
Allen P Burke1, Russell P Tracy, Frank Kolodgie
1Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306-6000, USA.
Circulation
|May 1, 2002
概括
高敏感性C反应蛋白 (hs-CRP) 水平在因严重冠状动脉疾病突然死亡的人群中升高. 这种升高与致命冠状动脉疾病的斑块特征和严重程度相关.
科学领域:
- 心血管病理学心血管病理学
- 生物标志物 生物标志物
- 法医病理学 法医病理学
背景情况:
- 高敏感性C反应蛋白 (hs-CRP) 的升高与不稳定的冠状动脉综合征有关.
- 没有先前的尸检研究将hs-CRP水平与致命的冠状动脉疾病结果相关联.
研究的目的:
- 调查死后hs-CRP水平与致命冠状动脉疾病之间的相关性.
- 在解剖案例中检查hs-CRP与特定动脉样硬化斑块特征之间的关系.
主要方法:
- 从302次解剖中对hs-CRP进行了测试.
- 将死亡人数分为动脉瘤 (破裂/侵蚀),稳定的斑块和对照组.
- 在冠状动脉斑块中的定量CRP免疫组织化学染色和薄盖动脉瘤.
主要成果:
- 与对照组相比,突然冠状动脉死亡 (破裂,侵蚀,稳定斑块) 的hs-CRP水平中位数显著更高.
- 多变量分析显示了与hs-CRP相关的动脉,稳定斑块和斑块负担,独立于其他危险因素.
- 较高的hs-CRP与斑块中CRP染色强度的增加以及更多的薄盖动脉瘤相关.
结论:
- 由于严重的冠状动脉疾病而导致的突然死亡时hs-CRP显著升高,不论是急性血栓形成.
- 死亡后的hs-CRP水平与动脉样硬化斑块内炎症的免疫组织化学证据相关.
- 研究结果表明hs-CRP是了解致命冠状动脉事件病理学的有价值的生物标志物.
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