天会从成年神经干细胞诱导神经发生
Hongjun Song1, Charles F Stevens, Fred H Gage
1Molecular Neurobiology Laboratory, Howard Hughes Medical Institute at the Salk Institute, 10010 North Torrey Pines Road, La Jolla, California 92037, USA.
Nature
|May 3, 2002
概括
海马中的成年星球细胞通过指示神经干细胞成为神经元来调节神经发生. 这一发现突显了星体细胞在成熟的中枢神经系统中的积极作用.
科学领域:
- 神经科学是一个神经科学.
- 干细胞生物学 干细胞生物学
- 天星细胞生物学 天星细胞生物学
背景情况:
- 传统上,星体细胞被认为是中枢神经系统的支持细胞.
- 神经发生,产生新神经元的过程,对大脑功能至关重要.
- 当地的环境显著影响神经干细胞的命运.
研究的目的:
- 研究当地的环境控制成年神经干细胞命运规范的机制.
- 为了确定星体细胞是否在成人海马中调节神经发生过程中发挥作用.
主要方法:
- 研究成年海马体中的星系细胞干细胞相互作用.
- 分析天体细胞对神经干细胞命运决定的影响.
主要成果:
- 来自海马的成年天体细胞可以指示神经干细胞采用神经元命运.
- 天体细胞在神经生成中的这种调节作用以前是意想不到的.
- 这些发现与最近关于天体细胞参与突触形成和传播的报道一致.
结论:
- 星球细胞积极调节成年大脑中的神经发生.
- 传统的看法是星球细胞纯粹是支持性的,正在被修订.
- 星球细胞在成熟的中枢神经系统的功能中起着至关重要的作用.
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