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在小鼠中致命的围产性血栓形成是由于组织因子通路抑制剂缺乏和V因子Leiden的相互作用而产生的

Daniel T Eitzman1, Randal J Westrick, Xiaoming Bi

  • 1Division of Cardiology, University of Michigan Medical Center, Ann Arbor, Mich 48109-0644, USA. deitzman@umich.edu

Circulation
|May 8, 2002
PubMed
概括

因素V莱登 (FVL) 增加了血栓形成的风险. 组织因子通路抑制剂 (TFPI) 水平的适度变化显著加剧了这种风险,这表明TFPI是FVL相关血栓形成的关键基因修饰剂.

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