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相关概念视频

Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...

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Quantification of Neurovascular Protection Following Repetitive Hypoxic Preconditioning and Transient Middle Cerebral Artery Occlusion in Mice
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循环氧化酶-1和二基斯特龙循环氧化酶-1/前环素合成酶基因转移可以预防缺血性脑梗塞.

Heng Lin1, Teng-Nan Lin, Wai-Mui Cheung

  • 1Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.

Circulation
|May 9, 2002
PubMed
概括

循环氧化原酶-1 (COX-1) 或COX-1/前环林合成酶 (PGIS) 的基因转移通过增加保护性前腺素来减少中风损伤. 这种COX-1基因疗法在治疗缺血性中风方面表现有前途.

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科学领域:

  • 神经科学是一个神经科学.
  • 分子生物学分子生物学
  • 遗传学 是一个遗传学.

背景情况:

  • 脑梗塞会导致严重的神经损伤.
  • 前列腺素是通过循环氧化酶酶合成的保护分子.
  • 基因转移为中风提供了一个潜在的治疗策略.

研究的目的:

  • 调查循环氧化酶-1 (COX-1) /前环林合成酶 (PGIS) 和COX-1基因转移是否可以减少脑梗塞的体积.
  • 要确定这种减少是否由保护性前列腺素的合成增加引起.

主要方法:

  • 携带COX-1 (Adv-COX-1) 或COX-1/PGIS (Adv-COX-1/PGIS) 的腺病毒载体被输入大鼠中风模型的侧心室.
  • 测量了COX-1,PGIS蛋白,eicosanoids和心脏病发作体积的水平.
  • 评估了选择性COX-1抑制剂对神经保护的影响.

主要成果:

  • Adv-COX-1/PGIS和Adv-COX-1基因转移增加了COX-1和PGIS蛋白的水平.
  • 广告-COX-1/PGIS选择性地增加了前环素水平,并显著减少了心脏病发作的数量,即使在缺血后5小时服用.
  • Adv-COX-1增加了前环素,抑制了白血素水平,并提供了类似的大脑保护,而这被COX-1抑制剂阻断了.

结论:

  • COX-1/PGIS和COX-1基因转移有效降低脑梗塞的体积.
  • 神经保护作用与前环素的增加和抑制白血素的产生有关.
  • 基于COX-1的基因转移为缺血性中风提供了潜在的治疗方法.