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Updated: Jul 7, 2026

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一个HIF-1alpha-pVHL复合物的结构:在信号传输中识别氧

Jung-Hyun Min1, Haifeng Yang, Mircea Ivan

  • 1Cellular Biochemistry and Biophysics Program and Howard Hughes Medical Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

Science (New York, N.Y.)
|May 11, 2002
PubMed
概括

·希佩尔-林道瘤抑制剂 (pVHL) 通过氧胺结合氧化缺氧诱导因子 (HIF),对氧气感应和细胞反应至关重要. 这种互动互动.

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Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
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The primary structure of a protein is its amino acid sequence.
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Protein Folding

Proteins are chains of amino acids linked together by peptide bonds. Upon synthesis, a protein folds into a three-dimensional conformation, critical to its biological function. Interactions between its constituent amino acids guide protein folding, and hence the protein structure is primarily dependent on its amino acid sequence.
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