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Updated: Jun 13, 2026

A Non-random Mouse Model for Pharmacological Reactivation of Mecp2 on the Inactive X Chromosome
08:27

A Non-random Mouse Model for Pharmacological Reactivation of Mecp2 on the Inactive X Chromosome

Published on: May 22, 2019

自体主导突变影响X无活化选择在小鼠

Ivona Percec1, Robert M Plenge, Joseph H Nadeau

  • 1Howard Hughes Medical Institute and Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

Science (New York, N.Y.)
|May 11, 2002
PubMed
概括

研究人员确定了哺乳动物X染色体失活所必需的新型自体因子. 这些遗传突变会影响早期胚胎发育过程中X染色体的沉默.

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In-vitro Mutagenesis01:16

In-vitro Mutagenesis

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.