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心脏膜脂肪酸成分调节心肌的氧气消耗和心肌收缩功能的后瘤恢复
Salvatore Pepe1, Peter L McLennan
1Cardiac Surgical Research Unit, Alfred Hospital and Baker Medical Research Institute, Monash University Faculty of Medicine, Melbourne, Australia.
Circulation
|May 16, 2002
概括
在老鼠中,食鱼油改善了心脏功能,减少了心肌氧消耗. 这表明鱼油.
科学领域:
- 心血管科学 心血管科学
- 营养科学 营养科学
- 生理学 生理学 生理学
背景情况:
- 定期食用鱼类与心血管疾病的减少有关.
- 鱼油改变心脏脂脂肪酸的组成,表现出抗心律失常的特性.
- 该研究调查了食鱼油对心室血动力学和心肌氧消耗 (MVO2) 的影响.
研究的目的:
- 为了评估食鱼油对心脏血液动力学的影响.
- 评估鱼油对心肌氧消耗 (MVO2) 的影响.
- 确定鱼油在心脏对缺血和再注血的反应中的作用.
主要方法:
- 雄性Wistar大鼠在16周内被食富含n-3PUFA (鱼油),n-6PUFA或和脂肪 (SAT) 的饮食.
- 隔离的工作心脏受到不同的工作负载或低流动性缺血,然后再输血.
- 测量了心肌氧消耗量 (MVO2) 和心脏功能标志物.
主要成果:
- 食n-3PUFA (鱼油) 的老鼠的心脏表现出较低的MVO2,较高的冠状动脉 perfusion 储量,以及在工作量下改善的心脏输出量.
- n-3 PUFA 饮食降低了缺血性标记物 (酸,K+,乳酸,CK) 并增强了反后的收缩性恢复.
- 用SAT养的老鼠心脏显示MVO2高, perfusion reserve低,功能差;通过KCl停止或红消除了对MVO2的饮食影响,但不是氨酸.
结论:
- 食鱼油直接增强心脏功能,改善对缺血/再输的反应.
- n-3 PUFA的消费降低了给定的工作负载的MVO2,并促进了后缺血性恢复.
- 这些直接的心肌效应可能有助于鱼类消费对心血管的益处.
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