脉压和与心血管疾病相关的死亡率:多重风险因素干预试验 (MRFIT) 的后续研究
Michael Domanski1, Gary Mitchell, Marc Pfeffer
1Division of Biostatistics, School of Public Health, 2221 University Ave SE, Room 200, Minneapolis, MN 55414, USA.
JAMA
|May 22, 2002
概括
缩和腹缩血压 (SBP/DBP) 比脉压更好地预测心血管疾病死亡率. 结合SBP和DBP可以改善男性的风险评估.
科学领域:
- 心脏病学 心脏病学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 联合国家委员会 (JNC-VI) 的分类使用心血管疾病 (CVD) 风险的压缩性血压 (SBP) 和压缩性血压 (DBP). 脉压也被认为是潜在的危险因素.
- 了解SBP,DBP和脉压的独立和综合预测值对于准确的CVD风险分层至关重要.
研究的目的:
- 为了比较SBP,DBP和脉压的关系,无论是单独的还是联合的,与男性的CVD相关死亡率.
- 评估这些血压参数如何与不同JNC-VI类别和年龄组的死亡率有关.
主要方法:
- 利用了多重危险因素干预试验 (MRFIT) 的数据,其中包括1973年至1975年期间选的35-57岁的342,815名男性.
- 根据SBP和DBP的JNC-VI类别对参与者的血压进行分类,并计算脉冲压.
- 通过1996年评估了与心血管疾病相关的死亡率,分析了与SBP,DBP和脉冲压的关系.
主要成果:
- 总共有25721例与心血管疾病相关的死亡记录.
- 与脉压相比,SBP和DBP与心血管疾病相关死亡率的关联性更强.
- 在SBP和DBP的一致升高增加了两年龄组的死亡风险;更高的SBP与较低的DBP也增加了老年男性 (45-57岁) 的风险.
结论:
- 与单独评估SBP,DBP或脉压力相比,考虑SBP和DBP一起提供了更好的心血管疾病风险评估.
- 这种综合方法增强了不同年龄段的男性的风险分层.
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