女性自己的出生体重与随后的妊娠糖尿病风险的关联
Kim E Innes1, Tim E Byers, Julie A Marshall
1Southeastern Rural Mental Health Center, McLeod Hall, University of Virginia, 202 15th St SW, Charlottesville, VA 22903-3306, USA. kei6n@virginia.edu
JAMA
|May 22, 2002
概括
一个女人的出生体重与她患妊娠糖尿病 (GDM) 的风险有关. 低或高出生体重会增加GDM风险,这表明早期生活因素会影响这种妊娠并发症.
科学领域:
- 产科和妇科 产科和妇科
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 孕期糖尿病 (GDM) 是一个重要的妊娠并发症,也是2型糖尿病的预测因素.
- 虽然胎儿生长与成年人2型糖尿病风险有关,但其与GDM相关性不太清楚.
研究的目的:
- 为了研究女性自身的胎儿生长和她随后发展GDM的风险之间的关系.
- 测试胎儿生长指数与GDM风险之间的逆关系假设.
主要方法:
- 一项基于人口的病例控制研究,利用纽约州的相关医院出院和生命记录.
- 从1994年至1998年期间的第一次怀孕中,参与了440名被诊断为GDM的妇女 (病例) 和22,955名没有GDM的妇女 (对照).
- 分析出生体重,调整为妊娠年龄,作为胎儿生长的主要指标.
主要成果:
- 在出生体重和GDM风险之间观察到U形关系,出生体重低 (<2000g) 和高 (≥4000g) 的风险都增加.
- 在调整了预孕BMI和母婴糖尿病等混因素后,与低出生体重相关的GDM风险的几率比为4.23.
- 在出生体重和GDM风险之间发现了强烈的逆剂量反应关系 (调整P为趋势<.001).
结论:
- 一个女人的出生体重与她患GDM的风险有显著和反向的联系.
- 这些发现凸显了早期生命因素,如胎儿生长在GDM发展中的潜在重要性.
- 表明早期生活影响可能在妊娠糖尿病病因学中发挥关键作用.
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