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相关概念视频

Paracrine Signaling01:21

Paracrine Signaling

Paracrine signaling allows cells to communicate with their immediate neighbors via secretion of signaling molecules. Such a signal can only trigger a response in nearby target cells because the signal molecules degrade quickly or are inactivated if not taken up. Prominent examples of paracrine signaling include nitric oxide signaling in blood vessels, synaptic signaling of neurons, the blood clotting system, tissue repair/wound healing, and local allergic skin reactions. Nitric oxide as a...
Nitric Oxide Signaling Pathway01:28

Nitric Oxide Signaling Pathway

Nitric oxide (NO), an inorganic gas, acts as a potent second messenger in most animal and plant tissues. NO diffuses out of the cells that produce it and enters the neighboring cells to generate a downstream response. NO synthase (NOS) catalyzes NO production by the deamination of the amino acid arginine. There are three isoforms of NOS. Endothelial cells have endothelial NOS (eNOS), nerve and muscle cells have neuronal NOS (nNOS), and macrophages produce inducible NOS (iNOS) upon exposure to...
Local Anesthetics: Differential Sensitivity of Nerve Fibers01:24

Local Anesthetics: Differential Sensitivity of Nerve Fibers

Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...
Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors01:20

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
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Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
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Diabetic Neuropathy

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相关实验视频

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Antigens Protected Functional Red Blood Cells By The Membrane Grafting Of Compact Hyperbranched Polyglycerols
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红葡萄酒中的多会通过两个不同的信号通路抑制血管光滑肌肉细胞迁移.

Katsuya Iijima1, Masao Yoshizumi, Masayoshi Hashimoto

  • 1Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Circulation
|May 22, 2002
PubMed
概括

红葡萄酒多 (RWPs) 通过阻断关键信号通路来抑制血管光滑肌肉细胞迁移,从而提供潜在的抗动脉增生效应. 这项研究澄清了RWPs.

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科学领域:

  • 心血管研究研究心血管研究
  • 分子生物学分子生物学
  • 药理学 药理学是指药理学的学科.

背景情况:

  • 红葡萄酒中的多 (RWPs) 具有抗动脉增生性质,主要是通过对LDL氧化的抗氧化作用.
  • 血管光滑肌肉细胞 (SMC) 迁移是动脉样硬化发展的关键因素.
  • 轮计划对中小企业迁移的具体影响在很大程度上仍未得到调查.

研究的目的:

  • 为了确定RWPs是否影响培养SMC的迁移.
  • 调查RWPs影响SMC迁移的潜在信号机制.

主要方法:

  • 评估RWP对血小板衍生生长因子 (PDGF-BB) 和血清诱导的SMC迁移的影响,使用伤口和博伊登腔检测.
  • 评估RWP对血管内皮细胞迁移的影响.
  • 研究了酸丁醇-3'激酶 (PI3K) 和基激活蛋白激酶 (MAPK) 途径 (p38(MAPK,ERK1/2) 在RWP介导的SMC抑制中的作用.

主要成果:

  • RWPs证明了PDGF-BB和血清诱导的SMC迁移的度依赖抑制,而不会影响血管内皮细胞.
  • PI3K和p38(MAPK的抑制剂,但不是ERK1/2,减少了PDGF-BB诱导的SMC迁移.
  • RWPs抑制PI3K活性和p38(MAPK) 酸化 (MK3 / 6的上游),与迁移抑制相关.

结论:

  • 通过抑制不同的PI3K和p38 (MAPK) 信号通路,RWPs有效地抑制SMC迁移.
  • 这些发现支持RWPs通过调节参与病变发展的关键细胞过程来支持其抗动脉增生潜力.