稳定的聚合物纳米气球:冷化和重水化交叉链接的脂质体
1Department of Chemistry, Carl S. Marvel Laboratories, University of Arizona, Tucson, Arizona 85721, USA.
Journal of the American Chemical Society
|May 23, 2002
概括
新的聚合性脂质可以产生强大的,交叉链接的脂质体. 这些稳定的结构能够承受干燥和再水,保持完整性和耐表面活性剂,适用于先进的应用.
科学领域:
- 超分子化学 超分子化学
- 材料科学 是一种材料科学.
- 脂质纳米技术的使用方法
背景情况:
- 超分子脂质组件容易被表面活性剂和酒精破坏.
- 稳定脂质组件对于它们的实际应用至关重要.
- 新型聚合性脂质提供了一种途径,可以创建强大的脂质结构.
研究的目的:
- 引入和表征新的异基生物功能聚合脂,烯酸/丹尼克 (Acrylic/DenPC) 16,18) 和烯酸/丹尼克 (Sorb/DenPC) 18,21).
- 为了证明交联脂质体在恶劣条件下的稳定性,包括冷化和再水.
- 研究防止在中性交联脂质体中聚合的方法.
主要方法:
- 合成异构功能性脂质 (乙/丹和/丹).
- 脂质体的形成和交叉链接.
- 解热化 (冷干燥) 和脂质体的再水.
- 使用准弹性光散射 (QELS) 和传输电子显微镜 (TEM) 进行表征.
- 对表面活性剂溶解的稳定性的评估.
主要成果:
- 交叉结合的脂质体在冷化和再水后表现出极好的稳定性,没有显著的尺寸或结构变化.
- 重水化交联脂质体仍然对表面活性剂诱导的破坏具有抵抗力.
- 中性交联脂质体在补水时显示出一些聚合,表面修饰可以减轻这种聚合.
- 纳入表面电荷或聚乙烯甘醇) 阻止了中性脂质体中的聚合.
结论:
- 异基生物功能聚合性脂质能够产生高度稳定的,交叉链接的脂质体.
- 交叉链接的脂质体表现出了显著的稳健性,能够在冷干燥和再水周期中存活下来.
- 表面修饰,如充电或PEGylation,可以有效地防止中性交联脂质体的聚合.
相关概念视频
Molecular Comparison of Gases, Liquids, and Solids
Particles in a solid are tightly packed together (fixed shape) and often arranged in a regular pattern; in a liquid, they are close together with no regular arrangement (no fixed shape); in a gas, they are far apart with no regular arrangement (no fixed shape). Particles in a solid vibrate about fixed positions (cannot flow) and do not generally move in relation to one another; in a liquid, they move past each other (can flow) but remain in essentially constant contact; in a gas, they move...
Comparing Intermolecular Forces: Melting Point, Boiling Point, and Miscibility
Intermolecular forces are attractive forces that exist between molecules. They dictate several bulk properties, such as melting points, boiling points, and solubilities (miscibilities) of substances. Molar mass, molecular shape, and polarity affect the strength of different intermolecular forces, which influence the magnitude of physical properties across a family of molecules.
Temporary attractive forces like dispersion are present in all molecules, whether they are polar or nonpolar. They...
Temporary attractive forces like dispersion are present in all molecules, whether they are polar or nonpolar. They...
Colloids
Children at play often make suspensions such as mixtures of mud and water, flour and water, or a suspension of solid pigments in water known as tempera paint. These suspensions are heterogeneous mixtures composed of relatively large particles that are visible to the naked eye or can be seen with a magnifying glass. They are cloudy, and the suspended particles settle out after mixing. On the other hand, a solution is a homogeneous mixture in which no settling occurs and in which the dissolved...
Intermolecular Forces and Physical Properties
Colloidal precipitates
The high insolubility of some precipitates can result in an unfavorable relative supersaturation. This can lead to colloidal particles with a large surface-to-mass ratio, where adsorption is promoted. For instance, in the precipitation of silver chloride, silver ions are adsorbed on the surface of the colloidal particles, forming a primary layer. This layer attracts ions of opposite charge (such as nitrate ions), forming a diffuse secondary layer of adsorbed ions. This electric double layer...
Micelles
Micelle formation is an intricate process that hinges on the properties of amphiphilic or amphipathic molecules and the conditions of the system in which they are found. Amphiphilic molecules, which have both hydrophilic (water-attracting) and hydrophobic (water-repelling) parts, play a critical role in this process.In aqueous environments, these molecules arrange themselves such that their hydrophilic heads are turned towards the water phase, while their hydrophobic tails are oriented away...


