快速恢复自组装的双块共聚二烯酸的水凝脚手架来自自组装的双块共聚二烯酸
Andrew P Nowak1, Victor Breedveld, Lisa Pakstis
1Department of Materials, University of California, Santa Barbara, California 93106, USA.
Nature
|May 25, 2002
概括
研究人员从双块共聚酸中开发了新的合成蛋白质水凝. 这些先进的生物材料具有显著的热稳定性和快速自我愈合特性,为生物技术应用提供了新的可能性.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 生物技术是生物技术.
背景情况:
- 基于蛋白质的水凝被广泛使用,但天然来源产生不一致的特性.
- 重组DNA方法使人工蛋白质水凝具有量身定制的特性.
- 合成方法为先进的应用提供了对材料特性的控制.
研究的目的:
- 为了合成和表征新型的双阻断共聚氨基两性化物用于水凝形成.
- 研究链条长度,组成和形状对水凝特性的影响.
- 探索这些合成水凝在生物技术中的潜力.
主要方法:
- 合成具有充电和疏水细分的双块共聚氨基两活体.
- 在稀释溶液中形成水凝的特征.
- 分析机械强度,热稳定性和应力后恢复.
- 研究链形状 (α螺旋,β链,随机线圈) 在凝中的作用.
主要成果:
- 在稀释溶液中,双块共聚氨基形态形成水凝,而不是微粒.
- 由此产生的水凝表现出高机械强度,高达90°C.
- 在施加应力后观察到机械性能的快速恢复.
- 发现凝取决于两性和多链形状.
结论:
- 特定形状的超分子组合对于这些合成多的凝至关重要.
- 开发了一种新的类型的基于的水凝,具有可调节的特性和刺激反应能力.
- 这些新型水凝对各种生物技术应用具有重大潜力.
相关概念视频
Dehydration Synthesis
Dehydration synthesis (also called a condensation reaction) is the chemical process in which two molecules covalently link together to form a new molecule, along with the release of a water molecule. Many physiologically important compounds form by dehydration synthesis reactions, such as complex carbohydrates, proteins, DNA, and RNA.Synthesis of carbohydratesSugar molecules are covalently linked together by dehydration synthesis. During the reaction, the hydroxyl (-OH) group from one reactant...
Hydrolysis
Overview
Hydrolysis is a chemical reaction in which the addition of water breaks down a polymer into its simpler monomer units. For example, peptides break into amino acids, carbohydrates into simple sugars, and DNA into nucleotides. Enzymes often facilitate these processes.
Hydrolysis Reverses Dehydration Synthesis
Complex carbohydrates can be broken down by breaking the bonds between individual sugar units. The reaction breaks a glycosidic bond as water is added to the compound. The...
Hydrolysis is a chemical reaction in which the addition of water breaks down a polymer into its simpler monomer units. For example, peptides break into amino acids, carbohydrates into simple sugars, and DNA into nucleotides. Enzymes often facilitate these processes.
Hydrolysis Reverses Dehydration Synthesis
Complex carbohydrates can be broken down by breaking the bonds between individual sugar units. The reaction breaks a glycosidic bond as water is added to the compound. The...
Cationic Chain-Growth Polymerization: Mechanism
The cationic polymerization mechanism consists of three steps: initiation, propagation, and termination. In the initiation step of the polymerization process, the π bond of a monomer gets protonated by the Lewis acid catalyst, which is formed from boron trifluoride and water. The protonation of the π bond generates a carbocation stabilized by the electron‐donating group. In the propagation step, the π bond of the second monomer acts as a nucleophile and attacks the generated carbocation,...
Types of Step-Growth Polymers: Polyesters
The introduction of polyesters has brought major development to the textile industry. The wrinkle-free behavior of polyester blends has eliminated the need for starching and ironing clothes.
Polyesters are commonly prepared from terephthalic acid and ethylene glycol; the crude product is known as poly(ethylene terephthalate) or PET. However, polyesters are synthesized industrially by transesterification of dimethyl terephthalate with ethylene glycol at 150 °C. The two reactants and the polymer...
Polyesters are commonly prepared from terephthalic acid and ethylene glycol; the crude product is known as poly(ethylene terephthalate) or PET. However, polyesters are synthesized industrially by transesterification of dimethyl terephthalate with ethylene glycol at 150 °C. The two reactants and the polymer...


