在患有阻塞性睡眠呼吸暂停的患者中,C-反应蛋白升高
Abu S M Shamsuzzaman1, Mikolaj Winnicki, Paola Lanfranchi
1Mayo Clinic Rochester, Rochester, MN 59905, USA.
Circulation
|May 30, 2002
概括
阻塞性睡眠呼吸暂停 (OSA) 与较高的C-反应蛋白 (CRP) 水平有关,这是炎症和心血管风险的标志物. 较高的CRP表明OSA的严重程度更高.
科学领域:
- 心脏病学 心脏病学
- 睡眠医学 睡眠医学
- 炎症研究 炎症研究
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 越来越多地与心血管和脑血管疾病有关.
- 在OSA的炎症过程可能会导致心血管疾病.
- 这项研究调查了OSA和C反应蛋白 (CRP) 水平之间的联系.
研究的目的:
- 为了测试OSA患者表现出血CRP水平升高的假设.
- 探索OSA严重程度和CRP水平之间的关系.
主要方法:
- 研究了22名新诊断的OSA患者,没有其他疾病或药物.
- 在OSA患者中比较的CRP水平与20岁的年龄和BMI匹配的对照组没有隐性OSA.
- 使用多变量分析来评估独立的关联.
主要成果:
- 与对照组相比,OSA患者的血CRP水平显著更高 (中位数为0.33对比0.09 mg/dL).
- 升高的CRP水平与OSA严重程度独立相关 (P=0.032).
结论:
- 阻塞性睡眠呼吸暂停与C反应性蛋白 (CRP) 水平升高有关.
- 在OSA患者中,CRP作为炎症和心血管风险的标志物.
- OSA的严重程度与CRP水平成正比.
相关概念视频
Tonsillitis I: Introduction
3.9K
Tonsillitis is inflammation of the tonsils, which are two lymphoid tissue masses at the back of the throat. This condition can cause discomfort and irritation in the throat.
Etiology
Three primary contributing factors have been identified.
Etiology
Three primary contributing factors have been identified.
3.9K
Acute Respiratory Failure-IV
824
Respiratory failure can manifest suddenly or gradually, characterized by a rapid decline in PaO2 and a rapid rise in PaCO2. This situation indicates a severe respiratory problem that may quickly become a life-threatening emergency. One of the early signs of hypoxemic Acute Respiratory Failure (ARF) is a change in mental status due to the brain's sensitivity to oxygen levels and changes in acid-base balance. Symptoms such as restlessness, confusion, and agitation suggest inadequate oxygen...
824
Chronic Obstructive Pulmonary Disease-II: Pathophysiology
5.0K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
5.0K
Sleep Apnea
914
Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
The condition is more prevalent among...
914
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
765
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
765
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features
40
Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
40


