冠状动脉热稀释以评估流量储备:对人类的验证
Nico H J Pijls1, Bernard De Bruyne, Leif Smith
1Department of Cardiology, Catharina Hospital, Eindhoven, the Netherlands. nico.pijls@inter.nl.net
Circulation
|May 30, 2002
概括
使用单个压力-温度传感器导线同时测量分数流量储备 (FFR) 和冠状动脉流量储备 (CFR) 是可行的. 这种方法简化了评估心脏微血管疾病.
科学领域:
- 心脏病学 心脏病学
- 医疗器械 医疗器械
- 生理学 生理学 生理学
背景情况:
- 评估心脏中的微血管疾病需要测量分数流量储备 (FFR) 和冠状动脉流量储备 (CFR).
- 目前的方法可能不允许同时测量FFR和CFR.
- 正在研究一种使用单个传感器尖端导线的新方法.
研究的目的:
- 为了确定使用单个压力-温度传感器导线同时测量FFR和CFR的可行性.
- 通过热稀释 (CFR ((thermo)) 测量的CFR与用多普勒 (CFR ((Doppl)) 测量的CFR进行比较.
主要方法:
- 一个带有压力-温度传感器的导线和一个多普勒导线在50名患者的103个冠状动脉中被使用.
- 冠状动脉热稀释曲线是在基线和高血压时使用盐水注射获得的.
- FFR是用冠状动脉压力来测量的,CFR (热) 是从运行时间计算的;CFR (双) 是从速度计算的.
主要成果:
- 同时测量FFR和CFR在87%的动脉中是可行的CFR (热) 和91%的CFR (双).
- CFR (热) 与CFR (双) (r=0.80,P<0.001) 呈现出良好的相关性.
- 在两种CFR测量之间,在25%的动脉中观察到显著的个体差异 (>20%).
结论:
- 在人类中使用单个导线同时测量FFR和CFR是可行的和实用的.
- 这种技术简化了对冠状动脉微血管疾病的评估.
- 综合测量有助于更全面地了解心脏血液动力学.
相关概念视频
01:29Blood Flow
Blood is pumped by the heart into the aorta, the largest artery in the body, and then into increasingly smaller arteries, arterioles, and capillaries. The velocity of blood flow decreases with increased cross-sectional blood vessel area. As blood returns to the heart through venules and veins, its velocity increases. The movement of blood is encouraged by smooth muscle in the vessel walls, the movement of skeletal muscle surrounding the vessels, and one-way valves that prevent backflow.
01:27Assessment of the Cardiovascular System III: Palpation
Palpation involves feeling the body to evaluate texture, size, consistency, and tenderness for assessing cardiovascular health. The following steps are organized in a head-to-toe order:
Jugular Venous Pressure (JVP) Measurement
Position the patient at a thirty- to forty-five-degree angle or in a semi-fowler's position. Look for the highest point of pulsation in the internal jugular vein and measure the vertical distance to the angle of Loius or sternal angle. A normal JVP is 3-4 cm above the...
Jugular Venous Pressure (JVP) Measurement
Position the patient at a thirty- to forty-five-degree angle or in a semi-fowler's position. Look for the highest point of pulsation in the internal jugular vein and measure the vertical distance to the angle of Loius or sternal angle. A normal JVP is 3-4 cm above the...