出版时间间隔与统计学意义之间的关联
Kay Dickersin1, Carin M Olson, Drummond Rennie
1Department of Community Health, Brown University, Providence, RI 02912, USA. kay_dickersin@brown.edu
JAMA
|June 1, 2002
概括
积极的临床试验结果不会比负面的结果发表得更快. 研究的质量和特征也没有影响对照试验的出版速度.
科学领域:
- 医学研究 医学研究
- 临床试验中的临床试验.
- 发表偏见的出版物偏见.
背景情况:
- 研究表明,人们倾向于更快地公布统计学上显著的临床试验结果.
- 这种现象被称为出版偏见,可以扭曲科学文献.
研究的目的:
- 为了调查报告受控临床试验的积极结果的手稿是否比报告负面结果的手稿更快地发表.
- 检查统计学意义,方法质量和出版时间之间的关联.
主要方法:
- 从1996年2月到1999年8月,向JAMA提交的经过追踪的手稿.
- 分类结果为积极的 (统计学上显著的初级结果) 或负的.
- 包括前性对照试验与统计比较,并接受出版.
主要成果:
- 在包括的133个手稿中,78%报告了积极的结果,38%报告了负面的结果.
- 从提交到出版的中位数时间对于阳性 (7.8个月) 和阴性 (7.6个月) 结果是相似的 (P=.44).
- 出版时间与方法质量或研究特征无关.
结论:
- 对受控试验的出版时间不受结果的统计学意义的影响.
- 方法质量和其他研究特征没有影响出版速度.
- 结果表明,与统计学意义相关的出版偏差可能在该特定期刊的受控试验出版物中不那么普遍.
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