中继体和转录控制在细胞因素信号转导中的作用
1Department of Genetics, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA. sheen@molbio.mgh.harvard.edu
Science (New York, N.Y.)
|June 1, 2002
概括
最近的研究强调了细胞激素,调节发育的植物激素的关键作用,通过详细的两组合信号通路模型. 这种模型,以阿拉比多普西斯为例,有助于理解植物的适应性.
科学领域:
- 植物生物学 植物生物学
- 分子植物生理学分子植物生理学
- 激素信号传递 激素信号传递
背景情况:
- 细胞因素是关键的植物激素,调节发育,影响植物的可塑性,适应性,弹性和永久生长.
- 最近的进展已经阐明了植物激素,特别是细胞因子的分子机制和作用.
- 植物表现出显著的敏感性和快速响应环境线索,通过荷尔蒙信号介导.
研究的目的:
- 概述了细胞因素信号传递的正规模型,一个多步骤的两部分路径.
- 在模型植物Arabidopsis中提供这种途径的具体例子.
- 介绍STKE连接地图,用于可视化正规和Arabidopsis特定的细胞因素信号通路.
主要方法:
- 关于细胞因素信号传递的最新研究的综述和综合.
- 专注于建立的双组件信号通路模型.
- 使用STKE连接地图进行路径可视化.
主要成果:
- 已经开发出了细胞因素信号传递的正规模型,该模型基于两组合的光继电系统.
- 这种模式在很大程度上在植物物种中得到保护,Arabidopsis作为一个关键的例子.
- STKE连接地图提供了一个可视化工具来探索一般和特定的路径.
结论:
- 规范的两部分信号通路模型为了解植物中细胞因素的作用提供了一个强大的框架.
- 细胞因素信号传递对植物发育可塑性和环境反应至关重要.
- 想象这些途径有助于进一步研究和理解植物激素网络.
相关概念视频
01:10Transcription
Overview
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds...
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds...
02:24Regulation of Expression Occurs at Multiple Steps
Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
01:17Transcription
Transcription is the synthesis of RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in correctly synthesizing messenger RNA (mRNA). Transcriptional regulation is responsible for the differentiation of different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds of RNA Molecules
In eukaryotes,...
Transcription Can Produce Different Kinds of RNA Molecules
In eukaryotes,...
02:24Regulation of Expression Occurs at Multiple Steps
Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
01:17Transcription
Transcription is the synthesis of RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in correctly synthesizing messenger RNA (mRNA). Transcriptional regulation is responsible for the differentiation of different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds of RNA Molecules
In eukaryotes,...
Transcription Can Produce Different Kinds of RNA Molecules
In eukaryotes,...
01:23Regulation of Expression at Multiple Steps
The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the addition of a...