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Fragility Assessment of Bovine Cortical Bone Using Scratch Tests
Published on: November 30, 2017
骨脆弱的发病因子在女性和男性
1Department of Endocrinology, Austin and Repatriation Medical Centre, Heidelberg 3084, Victoria, Australia. egos@unimelb.edu.au
Lancet (London, England)
|June 5, 2002
概括
骨脆弱性源于遗传和环境因素,导致骨密度降低. 衰老和更年期加速骨质流失,增加骨折风险,特别是在女性中,由于骨形成的补偿性较低.
科学领域:
- 骨生物学和老龄化问题
- 骨结构和脆弱性的骨结构.
- 激素对骨健康的影响
背景情况:
- 骨脆弱是遗传和环境因素影响骨密度,结构 (骨,皮层) 和峰值骨质量的结果.
- 骨重塑对于维持结构完整至关重要,随着年龄的增长而下降,导致净骨损失和损伤.
- 更年期引起的雌激素缺乏会通过增加吸收和减少形成加速女性的骨质损失.
研究的目的:
- 阐明骨脆弱性和与年龄相关的骨损失的多因素原因.
- 为了比较性别之间的骨损失机制和骨折易受性.
- 了解整个生命周期内骨脆弱的结构基础.
主要方法:
- 对骨重塑,遗传和环境影响的既定知识的审查.
- 分析骨代谢和结构变化的年龄和性别相关差异.
- 检查导致骨脆弱的因素,包括荷尔蒙和营养方面的因素.
主要成果:
- 老龄化导致骨形成相对于再吸收的减少,导致结构损伤和骨质损失在两性.
- 由于雌激素缺乏,女性在绝经后经历了加速的骨质损失,导致皮层和状骨变薄.
- 男人由于形成减少而经历骨质损失,其中阴性腺体缺陷和二次性甲状腺功能增强是导致因素;周骨骨形成提供了一些补偿,在男性中更大.
结论:
- 骨脆弱是发育,衰老和荷尔蒙因素的复杂相互作用,具有明显的性别特异性途径.
- 由于骨尺寸较小和补偿性骨周骨骨形成效果较差,女性更容易发生骨折.
- 骨脆弱的结构性决定因素在生命早期建立,并随着年龄的增长逐渐显现.
相关概念视频
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