为心力衰竭的长期治疗提供循环支持:用心室内连续流量的经验
Stephen Westaby1, Adrian P Banning, Satoshi Saito
1Oxford Heart Centre, Oxford, UK. swestaby@AHF.org.uk
Circulation
|June 5, 2002
概括
贾维克2000轴流为高级心力衰竭提供了可靠的机械解决方案. 这种连续流装置在临床试验中显著改善了患者的生活质量和本地心脏功能.
科学领域:
- 心脏病学 心脏病学
- 生物医学工程 生物医学工程
- 机械循环支持 机械循环支持
背景情况:
- 晚期心力衰竭需要可靠的机械解决方案,并发症风险低.
- 启动了一种轴流的临床试验,用于长期治疗纽约心脏协会IV类,移植不合格的患者.
研究的目的:
- 评估Jarvik 2000连续流装置作为末期心力衰竭的机械解决方案.
- 为了评估设备的可靠性,患者的结果,以及本地心脏功能.
主要方法:
- 贾维克2000是一款连续流装置,植入左心室顶部.
- 使用了基于头骨的皮肤穿透式输电.
- 四名患有末期扩张性心肌病的患者进行了运动能力,生活质量,设备参数和本源心脏功能的监测.
主要成果:
- 一名患者在3个月后死于右心力衰竭;另外三名患者的病情改善至纽约心脏协会I或II级.
- 随访时间为9至20个月,没有设备故障或血液溶解.
- 原生心脏功能和生活质量明显改善.
结论:
- 贾维克2000作为辅助装置,与本地左心室协同工作.
- 该设备提供了极好的生活质量,不经常出现不良事件.
- 这种血为基于社区的末期心力衰竭治疗提供了潜在的机械解决方案.
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